Registration Dossier
Registration Dossier
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EC number: 228-985-4 | CAS number: 6386-38-5
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Not GLP, non guideline study, no necropsy performed, no details on clinical observations, no body weigt data, no details on test animals, no details on exposure method (i.e. nose only)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 965
- Report date:
- 1965
Materials and methods
Test material
- Reference substance name:
- Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate
- EC Number:
- 228-985-4
- EC Name:
- Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate
- Cas Number:
- 6386-38-5
- Molecular formula:
- C18H28O3
- IUPAC Name:
- methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Details on inhalation exposure:
- The coarse crystals were placed in a hopper which fed the crystals into a 6" long teflon screw conveyor turned by a 4 r.p.m. clock motor. The crystals fell into the path of a high speed jet of air, and were thus blown (with some grinding effects) into a 72-liter all glass exposure chamber.
- Duration of exposure:
- 1 h
- Concentrations:
- 217 mg/liter
- No. of animals per sex per dose:
- 10 animals
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- > 217 mg/L air
- Mortality:
- no deaths occured
- Clinical signs:
- other: The rats were apparently unaffected both during exposure and a 14 day post exposure observation period.
- Body weight:
- no data
- Gross pathology:
- no data
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
