Registration Dossier
Registration Dossier
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EC number: 204-682-2 | CAS number: 124-12-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Guideline study, but with poor documentation.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Test type:
- standard acute method
Test material
- Reference substance name:
- Octanenitrile
- EC Number:
- 204-682-2
- EC Name:
- Octanenitrile
- Cas Number:
- 124-12-9
- Molecular formula:
- C8H15N
- IUPAC Name:
- octanenitrile
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sesam oil
- Doses:
- male/female: 2000 mg/kg bw
male: 1600 mg/kg bw ; 2500 mg/kg bw
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 160 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 for acute oral toxicity is LD50>2000 mg/kg bw.
- Executive summary:
An acute oral toxicity test to wistar rats was performed according to OECD401 guideline. The LD50 was determined to be for both male and female LD50>2000 mg/kg bw.
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