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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
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Diss Factsheets
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EC number: 202-088-8 | CAS number: 91-66-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from publication
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute inhalation toxicity of test chemical in mice
- GLP compliance:
- not specified
- Test type:
- fixed concentration procedure
- Limit test:
- no
Test material
- Reference substance name:
- N,N-diethylaniline
- EC Number:
- 202-088-8
- EC Name:
- N,N-diethylaniline
- Cas Number:
- 91-66-7
- Molecular formula:
- C10H15N
- IUPAC Name:
- N,N-diethylaniline
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): N,N-Diethylaniline
- Molecular formula: C10-H15-N
- Molecular weight: 149.236 g/mol
- Smiles notation: c1(N(CC)CC)ccccc1
- InChl: 1S/C10H15N/c1-3-11(4-2)10-8-6-5-7-9-10/h5-9H,3-4H2,1-2H3
- Substance type: Organic
- Physical state: Liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Not available
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- head only
- Vehicle:
- not specified
- Details on inhalation exposure:
- Details not available
- Duration of exposure:
- 4 h
- Concentrations:
- 533ppm, 644 ppm, 782 ppm, and 923 ppm
- No. of animals per sex per dose:
- 10 male rats each dose.
- Control animals:
- not specified
- Details on study design:
- Not specified
- Statistics:
- Not specified
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 4.14 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: 679 ppm equal to 4144.538 mg/m3
- Mortality:
- 533 ppm (2/10), 644 ppm (6/10), 782ppm (5/10), AND 923ppm (9/10).
- Clinical signs:
- other: CLINICAL SIGNS DURING AND IMMEDIATELY AFTER EXPOSURE INCLUDED: CYANOSIS, TREMORS, SEMIPROSTRATION, REDDISHBROWN NASAL DISCHARGE, HIND IMB ATAXIA, SALIVATION, AND ABNORMAL ARCHED BACK POSTURE. SIGNS OBSERVED AFTER 24 HOURS INCLUDED: STAINED PERINEAL AREA,
- Body weight:
- WEIGHT LOSS WAS OBSERVED 13 DAYS AFTER EXPOSURE; THEREAFTER NORMAL WEIGHT GAIN WAS SEEN.
- Gross pathology:
- Not specified
- Other findings:
- Not specified
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Conclusions:
- Acute inhalation toxicity in male rats was reported to be 679 ppm(4144.538 mg/m3 =4.144 mg/L).
- Executive summary:
- Acute inhalation toxicity for test chemical was studied in male rats. male rats(head only) were exposed for a single 4 hour period at a concentration of 533ppm, 644 ppm, 782 ppm, and 923 ppm. Clinical signs during and immediately after exposure included cyanosis, tremors, semi prostration, reddish brown nasal discharge, hind limb ataxia, salivation, and abnormal arched back posture. Signs observed after 24 hours included: stained perineal area, pallor, and reddish brown nasal discharge. Thus, LC 50 value was reported to be 679 ppm(4144.538 mg/m3=4.144 mg/l)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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