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EC number: 473-390-7
CAS number: -
log P at ca. 23 °C: 5.7 (OECD TG117, solubility ratio calculation)
The water and n-octanol
solubilities on which the log P estimate is based were measured using
scientifically valid methods and were conducted under GLP. The
solubility ratio method was applied due to the difficulty of accurate
measurement of FC-770 concentrations in aqueous samples at the level
necessary to conduct a shake-flask or slow-stirring method. Suitable
reference standards for an HPLC determination of the log P are not
available, nor are QSAR methods applicable to highly fluorinated
chemicals due to lack of an appropriate training set. The
solubility ratio method, while an estimate, provides a reasonable value
of partition coefficient. The
sources of error in extending solubility ratio to Pow, i.e.
the activities of the substance in water and n-octanol and the
dependence of activity on concentration, tend to cancel each other out
in the case of hydrophobic substances(1). Therefore,
this study is classified as reliable with restrictions. An
additional estimate of log Pow, obtained using the Rekker QSAR
method, could not be classified as to reliability since the algorithm
training set could not be evaluated.
1) S. H. Yalkowsky, S. C.
Valvani, T. J. Roseman. 1983. Solubility
and Partitioning VI: Octanol Solubility and Octanol-Water Partition
Pharm. Sci. Vol. 72, No. 8, pp. 866-870.
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