Registration Dossier
Registration Dossier
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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30-09-1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: Offhaus: Biological degradation-inhibition
- Qualifier:
- according to guideline
- Guideline:
- other: Sapromat for BOD
- Qualifier:
- according to guideline
- Guideline:
- other: Standard Methods German Waste Water Law for COD
- Principles of method if other than guideline:
- Chemical oxygen demand (COD) was assessed by standard methods. The biochemical oxygen demand (BOD) was analysed using a Sapromat BOD measuring unit. The BOD after 5 days was determined. Biological degradation-inhibition was performed according to the Offhaus method.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Tyrosine
- EC Number:
- 200-460-4
- EC Name:
- Tyrosine
- Cas Number:
- 60-18-4
- Molecular formula:
- C9H11NO3
- IUPAC Name:
- tyrosine
- Test material form:
- solid: particulate/powder
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- not specified
- Remarks:
- No data on activated sludge given.
- Duration of test (contact time):
- 5 d
Initial test substance concentrationopen allclose all
- Initial conc.:
- 422.3 mg/L
- Based on:
- COD
- Initial conc.:
- 206 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
Results and discussion
% Degradation
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 60.8
- Sampling time:
- 5 d
BOD5 / COD results
BOD5 / CODopen allclose all
- Parameter:
- BOD5
- Value:
- 1 248 mg O2/g test mat.
- Parameter:
- COD
- Value:
- 2 050 mg O2/g test mat.
- Key result
- Parameter:
- BOD5*100/COD
- Value:
- 60.8
Any other information on results incl. tables
The BOD5 test showed good biological degradation. The test item was degraded 60.8 % after a short exposure of 5 days.
The inhibition study showed negligible inhibition (1 %) and was decreasing.
Based on the observed respiration activity, it is expected that the biodegradation should take place undisturbed, even at higher concentrations and especially after certain adaptation.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The BOD5/COD*100 = 60.8%, the ultimate biodegradability exceeds 50 % within 5 days.
- Executive summary:
O-phospho-L-tyrosine dissociates in aqueous solutions. As according to REACH regulation only publicly available data has to be provided with the Registration dossier for on-site isolated intermediates in a tonnage band of < 1,000 t/a. Thus, information on the paren compound L-tyrosin is considered relevant and will be used for the registration dossier of O-phospho-L-tyrosine.
The biochemical oxygen demand (BOD) was analysed using a Sapromat BOD measuring unit and compared to the chemical oxygen demand (COD). Biological degradation-inhibition test was performed using the Offhaus method. It is not a GLP study and no OECD guideline was followed. After 5 days, the BOD5 was determined to be 1248 mg O2/g for L-tyrosine (COD = 2050 mg O2/g). The test is showing good biological degradation, i.e. 60.8 % after 5 days. L-tyrosine can be considered as readily biodegradable as the ultimate biodegradability exceeds 50 % within 5 days. The inhibition study showed negligible inhibtion of 1 % and decreasing.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.