2,6-dibromo-4-cyanophenyl octanoate

Toxicity to terrestrial arthropods

Link to relevant study record(s)

Reference

Endpoint:

toxicity to non-target arthropods on natural substrate (NTA other than pollinators)

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

Please refer to the Analogue Justification provided in IUCLID section 13

Reason / purpose for cross-reference:

read-across source

Key result

Duration:

28 d

Dose descriptor:

NOEC

Effect conc.:

>= 141 mg/kg soil dw

Nominal / measured:

nominal

Conc. based on:

act. ingr.

Basis for effect:

mortality

Key result

Duration:

28 d

Dose descriptor:

NOEC

Effect conc.:

>= 141 mg/kg soil dw

Nominal / measured:

nominal

Conc. based on:

act. ingr.

Basis for effect:

reproduction

Description of key information

From key source study (CAS 56634-95-8), the 28 -day NOEC for terrestrial arthropods exposed to the present test material was ≥141 mg a.i./kg dry weight soil.

Key value for chemical safety assessment

Long-term EC10, LC10 or NOEC for soil dwelling arthropods:

141 mg/kg soil dw

Additional information

Data on the long-term toxicity of the substance toterrestrial arthropods are not available. In accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5. , the assessment is based on the structurally analogue substance (CAS56634-95-8). Please refer to the attached analogue justification for further details on the read-across approach.

 

In the key source study (2014), the chronic toxicity of test substance to collembola (Folsomia Candida) was investigated after 28-day exposure according to OECD 232 (1999) guideline. The test item was incorporated into the soil. Ten female collembolan per replicate were exposed to a concentrations of 141 mg a.i./kg soil dry weight, alongside with a control. The reproduction NOEC was determined to be ≥ 141 mg a.i./kg soil d.w.

 

Additionally, three studies on Apis mellifera were conducted with the substance. The acute LD₅₀for adult honey bees was > 200 µg a.i./bee for both oral contact exposure. Another study resulted in a acute LD₅₀for adult honey bees of > 119.8 µg/bee for oral and 100 µg/bee for contact exposure.The 96 -h LD₅₀ and the NOED for larvae exposed to single exposure were 59.5 and 25.0 µg a.i./larva, respectively.