Registration Dossier
Registration Dossier
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EC number: 216-885-3 | CAS number: 1689-99-2
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
The PBT Assessment is based on the criteria set out in the “Guidance on information requirements and chemical safety assessment, Chapter R.11: PBT Assessment” (ECHA, 2017).
Persistence (P) Assessment
The substance 2,6-dibromo-4-cyanophenyl octanoate is not readily biodegradable according to OECD criteria (37% after 28 days; OECD 301B). The degradation half-life of 2,6-dibromo-4-cyanophenyl octanoate in two sediment water systems ranged from 4.2 to 8.5 hours (recalculated to 12 °C). The main degradation product in water and sediment was 3,5-dibromo-4-hydroxybenzonitrile. After 100 days 14CO2 formation accounted for 55.2 and 55.4% AR.
In soil, the substance attained 29.4 – 55.1% degradation (elevation of 14CO2) after 35 days and 19.4 °C, and the half-life of the test substance in soil was found to range from 0.14 – 0.62 days (0.28 – 1.25 days, recalculated to 12 °C)
The degradation of the transformation product and structural analogue [14C]-3,5-dibromo-4-hydroxybenzonitrile (CAS 1689-84-5) was investigated in natural water samples under aerobic conditions. Under the conditions of the test 3,5-dibromo-4-hydroxybenzonitrile remained stable (DT50 = >1000 days).
Based on the available data on the degradation product 3,5-dibromo-4-hydroxybenzonitrile, the target substance 2,6-dibromo-4-cyanophenyl octanoate is assessed as vP/P.
Bioaccumulation (B) assessment
The experimentally determined log Pow of 5.9 of 2,6-dibromo-4-cyanophenyl octanoate indicates a potential for bioaccumulation. However, a study on the bioconcentration in fish determined a BCF of 180 ± 40 (whole fish). Therefore, the substance does not meet the B criterion.
Toxicity (T) assessment
The substance is classified as H361d (“Suspected of damaging the unborn child”) and thus assessed as T.
Effect concentrations determined in chronic aquatic toxicity tests were < 0.01 mg/L.
Summary and overall conclusions on PBT or vPvB properties
Overall conclusion:
Based on the assessment described in the subsections above the substance is not PBT.
Justification:
According to Annex XIII of the REACH Regulation (EC) No 1907/2006, a PBT substance has to meet all three of the criteria for persistence, bioaccumulation and toxicity, as listed in part 1 of Annex XIII, and a vPvB substance has to meet all criteria for persistence and bioaccumulation, as listed in part 2 of Annex XIII. Based on the relevant data provided and discussed, the substance is identified as vP and T, the substance is not identified as PBT or vPvB.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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