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EC number: 405-520-5 | CAS number: 95235-30-6 D-8; DD-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 1988-08-23 to 1988-12-24
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- No sampling procedure indicated.
- Buffers:
- McIlvaine buffer solution for pH 4:
0.1 M citric acid + 1 N sodium hydroxide (8:2) (55.1 mL)
0.1 N hydrochloric acid (44.9 mL)
Distilled water (950 mL)
Soerensen buffer solution for pH 7:
M/15 potassium phosphate, monobasic (41.3 mL)
Sodium phosphate, dibasic (58.7 mL)
Distilled water (950 mL)
Clark and Lubs buffer solution for pH 9:
0.005 M borax (417 mL)
0.1 N hydrochloric acid (83 mL)
Distilled water (500 mL)
Adjusted to pH 9 with 0.1 N NaOH - Details on test conditions:
- The test solutions at the indicated pH values were stored at 50 ± 1 °C for the required time (24, 48, 72, 96 and 120 hours).
- Duration:
- 24 h
- Temp.:
- 50 °C
- Initial conc. measured:
- 14.68 mg/L
- Remarks:
- pH 4, 7 and 9
- Duration:
- 48 h
- Temp.:
- 50 °C
- Initial conc. measured:
- 14.68 mg/L
- Remarks:
- pH 4, 7 and 9
- Duration:
- 96 h
- Temp.:
- 50 °C
- Initial conc. measured:
- 14.68 mg/L
- Remarks:
- pH 4, 7 and 9
- Duration:
- 120 h
- Temp.:
- 50 °C
- Initial conc. measured:
- 14.68 mg/L
- Remarks:
- pH 4, 7 and 9
- Number of replicates:
- Two measurements were performed per pH condition.
- Positive controls:
- no
- Negative controls:
- no
- Preliminary study:
- The results of the preliminary test indicated in the guideline showed that the recovery of D-8 was more than 96 % after 5 days at 50 °C and pH 4, 7 and 9. Thus, it was concluded that D-8 is hydrolytically stable.
- Transformation products:
- not measured
- % Recovery:
- > 96 - < 102
- pH:
- 4.07
- Temp.:
- 50 °C
- Duration:
- >= 24 - <= 120 h
- Remarks on result:
- hydrolytically stable based on preliminary test
- % Recovery:
- > 97 - < 102
- pH:
- 7.1
- Temp.:
- 50 °C
- Duration:
- >= 24 - <= 120 h
- Remarks on result:
- hydrolytically stable based on preliminary test
- % Recovery:
- > 97 - < 102
- pH:
- 8.92
- Temp.:
- 50 °C
- Duration:
- >= 24 - <= 120 h
- Remarks on result:
- hydrolytically stable based on preliminary test
- Key result
- Remarks on result:
- hydrolytically stable based on preliminary test
- Details on results:
- The hydrolysis of D-8 in aqueous solutions was tested in accordance with OECD Guideline 111. The results of the preliminary test indicated in the guideline showed that the recovery of D-8 was more than 96 % after 5 days at 50 °C and pH 4, 7 and 9. Thus, it was concluded that D-8 is hydrolytically stable.
- Validity criteria fulfilled:
- yes
- Conclusions:
- D-8 was tested for hydrolytic stability in aqueous solutions at pH 4, 7 and 9 according to OECD Guideline 111. The results of the preliminary test showed that the recovery of D-8 was more than 96 % for 5 days at 50 °C and pH 4, 7 and 9. It was concluded that D-8 is hydrolytically stable.
- Executive summary:
D-8 was tested for hydrolytic stability in aqueous solutions according to OECD 111. The pH values tested were 4, 7 and 9. The samples were incubated at 50 °C for 24, 48, 72, 96 and 120 hours. The results showed a recovery of D-8 of more than 96 % for 5 days at 50 °C. Thus, it was concluded that D-8 is hydrolytically stable.
Reference
The recovery of D-8 under each condition in this experiment is summarized in the table.
The recoveries at any pH were more than 96 % for 5 days and more than 99 % at 5 days.
Therefore, it was concluded that D-8 is stable at 50 °C in acidic, neutral and basic solutions.
Table: Recovery of D-8 in Hydrolysis Study.
Incubation time |
Recovery ( % of applied D-8*) at pH |
|||
(hrs) |
pH |
4.07 |
7.10 |
8.92 |
0 |
1 |
96.0** |
97.9 |
100.8 |
2 |
96.7 |
101.9 |
101.4 |
|
Av. |
96.4 |
99.9 |
101.1 |
|
24 |
1 |
102.3 |
100.3 |
99.2 |
2 |
101.7 |
101.8 |
99.2 |
|
Av. |
102.0 |
101.1 |
99.2 |
|
48 |
1 |
99.9 |
100.0 |
100.2 |
2 |
101.7 |
101.6 |
100.7 |
|
Av. |
100.8 |
100.8 |
100.5 |
|
72 |
1 |
101.1 |
100.6 |
97.7 |
2 |
100.1 |
101.3 |
98.0 |
|
Av. |
100.6 |
101.0 |
98.0 |
|
96 |
1 |
99.9 |
98.8 |
100.2 |
2 |
100.4 |
100.8 |
100.3 |
|
Av. |
100.2 |
99.8 |
100.3 |
|
120 |
1 |
102.4 |
99.5 |
99.9 |
2 |
101.3 |
99.3 |
98.5 |
|
Av. |
101.9 |
99.4 |
99.2 |
* Initial concentration of D-8 : 5.02E-5 M (14.68 mg/L).
** Figures are mean values of 2 measurements.
Description of key information
D-8 is hydrolytically stable at pH 4, 7 and 9.
Key value for chemical safety assessment
Additional information
D-8 was tested for hydrolytic stability in aqueous solutions according to OECD 111. The pH values tested were 4, 7 and 9. The samples were incubated at 50 °C for 24, 48, 72, 96 and 120 hours. The results showed a recovery of D-8 of more than 96 % for 5 days at 50 °C. Thus, it was concluded that D-8 is hydrolytically stable.
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