Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 405-520-5 | CAS number: 95235-30-6 D-8; DD-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Appearance/physical state/colour
D-8 is a solid white and odourless substance.
Melting point/freezing point
The melting point of D-8, 4-[[4 -(1-methylethoxy)phenyl]-sulfonyl]phenol, was determined by the method of OECD Guideline 102: Melting point/Melting range (1981). The melting point of D-8 was determined to be 402.4 K (129.3 °C) using a photocell detection method in accordance with the guideline.
Boiling point
D-8 was investigated for boiling temperature according to EU method A.2. As the boiling point could not be measured at atmospheric pressure because the test item decomposed, it was measured under reduced pressure using a standard laboratory procedure not specified in the Official Journal. The boiling point of D-8 has been determined to be 363 K with decomposition, at a pressure of 2.128 kPa.
Density
D-8 was tested for relative density by the pycnometer method according to EU Test guideline A 3. The relative density of D-8 was found as 1.2914 g /cm³ at 21.0 ± 0.5 °C.
Particle size distribution (Granulometry)
The particle distribution of D-8 was measured using the Laser Diffraction technique. The substance is dispersed in a suitable medium and the diffraction of a laser beam is measured. For D-8, in the tested sample, the mean particle size was found to be 5.12 µm.
Vapour pressure
The vapour pressure of D-8 was measured by a gas saturation method as described in the OECD Guideline 104. The vapour pressure of D-8 was less than 1E-5 Pa at 27 °C.
Partition coefficient
The n-octanol/water partition coefficient of D-8 was determined by the flask shake method according to OECD Guideline 107. The log Pow for D-8 was found as 3.36 ± 0.067 at 25 °C.
Water solubility
The solubility of D-8 in distilled water was determined according to the method CIPAC MT 10. The solubility of D-8 in distilled water was 19.7E-3 g/L at a pH of 6.85 and 25 °C.
Solubility in organic solvents / fat solubility
The solubility of D-8 in Standard Fat was determined in accordance with OECD Guideline 116. The solubility of D-8 was found to be 0.891 g/kg of Standard Fat at 37 °C.
Surface tension
D-8 was tested for surface tension of aqueous solutions of the test material according to EU Method A.5. The surface tension of a solution of 0.0293 g of test material was detected to 68.6 mN/m at 21.5 ± 0.5 °C. The test material is not considered to be a surface-active material.
Flash point
A flash point is defined only for liquid substances. In Regulation 1272/2008/EC, liquids are defined as follows: Liquid means a substance or mixture which: (i) at 50 °C has a vapour pressure of not more than 300 kPa (3 bar); (ii) is not completely gaseous at 20 °C and at a standard pressure of 101,3 kPa; and (iii) which has a melting point or initial melting point of 20 °C or less at a standard pressure of 101,3 kPa;
D-8 is a solid with a melting point of 129 °C. Therefore, the measurement of a flash point is not necessary.
Auto Flammability
The relative self-ignition temperature for D-8 has been determined according to the EU Guideline A.16. The test substance was suspended in a wire mesh cube in an oven at room temperature. The temperature/time curve relating to the condition, in the centre of the sample and in the oven were recorded while the temperature of the oven was increased to approximately 390 °C at a rate of 0.5 °C/min. The relative self-ignition temperature of D-8 has been found to be greater than the melting temperature of 129 °C.
Flammability
D-8 was tested for the flammability of solids according to the EU Test guideline A.10. Powdery, granular or paste-like substances are to be considered as highly flammable when the time of burning in any tests carried out according to the test procedure as described is less than 45 sec. D-8 was not shown to be highly flammable as it did not propagate combustion. D-8 was not classified and labelled highly flammability, according to Regulation (EC) No 1272/2008 (CLP).
Explosiveness
D-8 was tested for explosive properties according to EU Test guideline A.14 in the three following tests:
1) Shock of a falling load (BAM Fallhammer Test);
2) Friction (BAM Friction Test);
3) Heating under confinement (KOENEN Test).
Each test was performed six times. In none of the three performed tests, D-8 showed any sign of explosive properties.
Oxidising properties
D-8 was tested for oxidising properties in a test according to EU Gudeline A.17. D-8 has been determined to be an oxidiser since the maximum burning rate of the test substance mixtures with cellulose was greater than that of the reference substance mixtures with cellulose. The test substance is a solid with a comparatively low melting point however, so this result could have been a false positive. D-8 did not support combustion when mixed with an inert material, celite. Consequently, the result obtained in the standard oxidising properties test A.17 is considered to be valid, and the substance is confirmed to be an oxidiser.
Stability in organic solvents and identity of relevant degradation products
The test of stability in organic solvents and identification of reaction products is only necessary, if stability of a substance is considered a critical property. This does not apply to D-8. Therefore, testing of the stability of D-8 in organic solvents was not considered relevant.
Dissociation constant
The determination of the dissociation constant of D-8 is technically not feasible. REACh Regulation Annex IX, Sect. 7.16, Col. 2, states as follows: “7.16: Dissociation constant.: The study does not need to be conducted if: - the substance is hydrolytically unstable (half-life less than 12 hours) or is readily oxidisable in water, or - it is scientifically not possible to perform the test for instance if the analytical method is not sensitive enough.”
For the determination of the dissociation constant of a substance, it is necessary to determine the hydrolysis of the substance at all. In a hydrolysis test D-8 was found to be a substance highly stable to hydrolysis at pH-values of 4, 7 and 9. Therefore, the hydrolysis of D-8 in water was not determinable in a suitable manner. Consequently, the determination of the dissociation constant of D-8 is not practicable.
Calculation of the Dissociation constants with the SPARC v 4.5 online calculating programme for estimation of chemical parameters showed the following results: pKa: 8.24
Viscosity
The determination of the viscosity is scientifically unjustified. Viscosity is an intrinsic property of a fluid and a dimension for the viscidity of a fluid medium. D-8 is a powdery solid with a melting point of 129 °C. Therefore, no properties which can be applied for a fluid are present in D-8 at ambient conditions. As a result, the determination of the viscosity is scientifically unjustified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.