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Toxicological information

Repeated dose toxicity: oral

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Administrative data

Endpoint:
short-term repeated dose toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Cross-reference
Reason / purpose:
read-across: supporting information

Data source

Reference
Reference Type:
review article or handbook
Title:
2-METHYLPENTANE (ISOHEXANE)
Author:
Galvin, Jennifer B.; Bond, Gary
Year:
1999
Bibliographic source:
Journal of Toxicology and Environmental Health, Part A, 58:1-2, pp. 81-92, DOI: 10.1080/009841099157449; http://dx.doi.org/10.1080/009841099157449

Materials and methods

Test material

Reference
Name:
Unnamed
Test material form:
liquid

Test animals

Species:
rat
Strain:
Fischer 344
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Duration of treatment / exposure:
28 d
Frequency of treatment:
once daily, 5 d/wk
Doses / concentrationsopen allclose all
Dose / conc.:
500 mg/kg bw/day (nominal)
Dose / conc.:
2 000 mg/kg bw/day (nominal)

Results and discussion

Any other information on results incl. tables

In the ranking from highest to lowest, 2-methylpentane was last or lowest (questionable) among those that were positive for nephrotoxicity; statistically significant elevated nephropathy scores compared with saline controls; at 2000 mg/kg, lower body weight.

Applicant's summary and conclusion

Conclusions:
The study showed statistically significant elevated nephropathy scores compared with saline controls, and, at 2000 mg/kg, lower body weight.
Executive summary:

Halder et al. carried out a series of 28 -d gavage (oral) screening studies in male F344 rats to identify the major contributors to this nephropathy. Tested were PS-6 reference gasoline, some fractions of this gasoline, and 15 individual components of gasoline, including 2-methylpentane. In all, 0.5 or 2 g/kg of 22 different hydrocarbon materials was administered once a day by gavage for 5 d/wk for 28 d.

Halder, C. A., Holdsworth, C. E., Cockrell, B. Y., and Piccirillo, V. J. 1985. Hydrocarbon nephropathy in male rats: Identification of the nephrotoxic components of unleaded gasoline. Toxicol. Ind. Health 1:67–87.