Registration Dossier
Registration Dossier
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EC number: 214-093-2 | CAS number: 1079-66-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study available in EPA (TSCA8e submission file). The study was not performed under GLP. The data are well documented and the data acceptable
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The procedure employed is in accordance with the test for eye irritation outlined in the Code of Federal Regulations (Part 191.12, Chap. 1, Title 21) for evaluating hazardous substances.
The test material was placed in one of each animal by gently pulling the lower lid away from the eyeball. The other eye, remaining untreated, served as the control. Animals were observed at 24, 48, and 72 hours following treatment and scored for irritation properties.
Eye irritation was determined according to the method outlined in the "Illustrated Guide for Grading Eye Irritation by Hazardous Substances". A total score of 110 is possible. A non-irritant must have a score of 10 or less. If, at the end of 72 hours ocular damage appears to be remissible (reversible), the animal is observed for an additional 4-7 days before final scoring is possible. - GLP compliance:
- no
Test material
- Reference substance name:
- Chlorodiphenylphosphine
- EC Number:
- 214-093-2
- EC Name:
- Chlorodiphenylphosphine
- Cas Number:
- 1079-66-9
- Molecular formula:
- C12H10ClP
- IUPAC Name:
- diphenylphosphinous chloride
- Test material form:
- liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 100 mg or 0.1 mL
- Observation period (in vivo):
- 24, 48 or 72h following treatment
- Number of animals or in vitro replicates:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Remarks:
- destruction of entire eye structure
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Remarks:
- destruction of entire eye structure
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Remarks:
- destruction of entire eye structure
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Remarks:
- destruction of entire eye structure
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- Based on the findings of the in vivo study with rabbits, the test substance is considered to be corrosive to the eyes.
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