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EC number: 248-655-3 | CAS number: 27776-21-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- The study was undertaken between 17. October and 6. November 1986
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,2'-Azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride
- Cas Number:
- 27776-21-2
- IUPAC Name:
- 2,2'-Azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride
- Test material form:
- solid: particulate/powder
- Remarks:
- particle size not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- All rats were acclimated to the experimental environment for a minimum of 7 days prior to the start of the main study. The rats were randomly allocated to cages within the treatment groups. They were house in groups by sex in metal cages with wire mesh floors. A standard laboratory rodent diet and water were provided ad libitum.
Temperature: 20 - 23 °C
Relative humidtiy: 62%
Air exchange: 15/h
Aritificial light: 12h in each 24 hour period
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- methylcellulose
- Details on oral exposure:
- The test substance was administered to each rat using a syringe and plastic catheter
- Doses:
- 1.6 g/kg
2.5 g/kg
3.2 g/kg
4.0 g/kg - No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
- Preliminary study:
- The results of the preliminary studies indicated that the LD 50 of VA-044 was in the region of 2500 mg/kg BW
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2 800 mg/kg bw
- Based on:
- test mat.
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 3 200 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 3 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Death occurred amongst rats treated at 2.5 g/kg BW and above generally within one and three hours of dosing. One animal treated at 4.0 g/kg was found dead an Day 2.
- Clinical signs:
- other: Pilo - erection was observed shortly after dosing in all rats. Abnormal body carriage (hunched posture) also observed in all rats treated at 1.6, 2.5 and 3.2 g/kg and in thre rats treated at 4.0 g/kg bw. These signs were accompaniedby: abnormal gait (wa
- Gross pathology:
- Renal pallor was observed at autopsy of the rat found dead on Day 2.
Autopsy findings of all other rats that died were normal
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute median lethal oral dose (LD50) and their 95 % confidence limits to rats of VA-044 were estimated to be:
Males and females combined: 3000 mg/kg bw
Males only : 3200 mg/kg bw
Females only : 2800 mg/kg bw
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