Registration Dossier
Registration Dossier
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EC number: 204-198-1 | CAS number: 117-57-7
Endpoint summary
Administrative data
Description of key information
The substance shall be registered under Article 18 (transported isolated intermediate) < 1000 t/a; no testing is required; however, an indicative assessment of potential skin sensitizing properties based on non-testing methods is included in this IUCLID.
This indicative assessment of skin sensitizing properties is based on physico-chemical, toxicological, and in silico data. Experimental studies have not been performed for this endpoint.
The substance is of moderate acute oral and of low acute dermal toxicity in vivo. It is not irritating to rabbit’s skin. In occupational settings no skin effects as skin irritation or skin sensitization were reported. The substance showed no electrophilicity in an Ames test in vitro on 4 Salmonella strains.
According to the physico-chemical properties of the substance (solid with MW 203, moderate solubility in water, log Pow 2.94) dermal absorption can be expected. No skin sensitization alerts were identified in silico by the OECD Toolbox.
In conclusion, the limited available information in this indicative evaluation does not point to a relevant skin sensitization potential in vivo.
Key value for chemical safety assessment
Justification for classification or non-classification
The substance is registered under Article 18 (transported isolated intermediate) < 1000 t/a; no testing is required; however, an indicative assessment of potential skin sensitizing properties based on non-testing methods is included in this IUCLID.
In conclusion, the limited available information in this indicative evaluation does not point to a relevant skin sensitization potential in vivo.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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