Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
significant methodological deficiencies
Remarks:
THE PRODUCT WAS ADDED TO THE TEST WATER WITHOUT ANY PRETREATMENT; SUBSEQUENTLY THE FISH WERE PLACED THE AQUARIUM CONTENTS WERE COLORED AND CLOUDY AND UNDISSOLVED TEST SUBSTANCE WAS VISIBLE

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Report date:
1991

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: DIN 38 412 "TESTVERFAHREN MIT WASSERORGANISMEN (GRUPPE L). ALLCEMEINE HINWEISE ZUR PLANUNG, DURCHFUEHRUNG UND AUSWERTUNG BIOLOGISCHER TESTVERFAHREN (L1)-- UND ‹BESTIMMUNG DER WIRKUNG VON WASSERINHALTSSTOFFEN AUF FISCHE - FISCHTEST (L15)--, JUNE 1982,
Deviations:
not specified
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3-hydroxy-2-methylquinoline-4-carboxylic acid
EC Number:
204-198-1
EC Name:
3-hydroxy-2-methylquinoline-4-carboxylic acid
Cas Number:
117-57-7
Molecular formula:
C11H9NO3
IUPAC Name:
3-hydroxy-2-methylquinoline-4-carboxylic acid
Test material form:
solid

Sampling and analysis

Analytical monitoring:
no

Test solutions

Vehicle:
no
Details on test solutions:
Test concentrations: 2150 mg/L, 4640 mg/L, 10000 mg/L

Test organisms

Test organisms (species):
Leuciscus idus
Details on test organisms:
SUPPLIER: FISCHZUCHT PAUL EGGERS
D-W2354 HOHENWESTEDT, FRG
BODY LENGTH: 5.3 CM (RANGE: 4.2 - 6.0)
BODY WEICHT: 1.7 G (RANGE: 0.8 - 2.4)

Study design

Test type:
flow-through
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h

Test conditions

Hardness:
2.5 MMOL/L,
RATIO Ca/Mg IONS 4 :1
RATIO Na/K IONS :10 :1
Test temperature:
21-22°C
pH:
7.7 to 7.9 in control
5.9 to 6.3 in treated solutions
Dissolved oxygen:
7.5 to 9.1 mg/L in control
8.1 to 8.6 mg/L in treated solutions
Salinity:
294.0 MG/L CACL2 .2 H20
123.3 mg/L MgSO4 .7 H20
63.0 mg/L NaHCO3
5.5 mg/L KCL
Details on test conditions:
PHOTOPERIOD: 16 HOURS LIGHT AND 8 HOURS DARK
Reference substance (positive control):
yes
Remarks:
CHLOROACETAMIDE LC 50 AFTER 48 H: ABOUT 32 mg/L

Results and discussion

Effect concentrations
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
9 535 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)

Applicant's summary and conclusion

Validity criteria fulfilled:
not specified
Conclusions:
The study is considered invalid as the pre-treatment of the test substance consisted of a simple adding of test substance to the water. No filtration occured and fish were kept in aquaria with turbid water.