Registration Dossier
Registration Dossier
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EC number: 290-649-8 | CAS number: 90194-39-1
Endpoint summary
Administrative data
Description of key information
The PNEC for soil for LAS was determined to be 35 mg/kg in the European Union (EU) Risk Assessment of LAS (Jensen et al , 2007).
For completeness, the PNECsoil of 3.5 mg/kg is proposed for LAS DEA, applying a precautionary assessment factor of 10. Please refer to read-across justification attached to IUCLID Section 13.
Additional information
No experimental data on terrestrial toxicity is available for the test item. However, experimental data for one read-across substance is available and a read-across approach is applied. Please refer to read-across justification document attached in IUCLID Section 13. Furthermore, only key studies are taken into account here. For further supporting information please refer to corresponding REACH registration dossier of the source substance.
A PNECsoil for LAS-NA was derived in the European Union (EU) Risk Assessment of LAS (Jensen et al , 2007). The EU undertook a review of studies on the toxicity of LAS to soil macro-organisms and terrestrial plants in order to determine a predicted level of no adverse effects (PNEC) in soil.
Nine invertebrate studies and 12 plants studies were used to calculate the PNEC. Full references for all studies are provided in the corresponding dossier. In all the plant experiments, LAS was added as an aqueous solution, and the most sensitive endpoint - growth - was used in the PNEC calculation. In cases where an NOEC or EC10value was not reported, the original data or graphical estimations were used to calculate the EC10value. This was considered more appropriate than using an arbitrary extrapolation factor. Invertebrate data were based on 9 chronic studies. In cases where there was more than one study on a particular species, a geometric mean of the data was used. The data for both sets of studies were merged as the sensitivity of both types of species were similar. This was confirmed by the Kolmogorov-Smirnov test. The species sensitivity distribution was then calculated. From this, the concentration that would exceed NOEC or EC10 for 5% of species was calculated (HC5). Based on this information, the HC5was determined to be 35.3 mg/kg soil. The 95% confidence interval was 18.6-50.0 mg/kg.
The PNEC for soil was determined to be 35 mg/kg. For completeness, the PNECsoil of 3.5 mg/kg is proposed for LAS DEA, applying an assessment factor of 10.
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