Registration Dossier
Registration Dossier
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EC number: 203-142-3 | CAS number: 103-76-4
Guidance on Safe Use
Administrative data
First-aid measures
4.1. Description of first aid measures
Remove contaminated clothing.
If inhaled:
Keep patient calm, remove to fresh air, seek medical attention. Immediately administer a corticosteroid from a controlled/metered dose inhaler.
On skin contact:
Wash thoroughly with soap and water. If irritation develops, seek medical attention.
On contact with eyes:
Immediately wash affected eyes for at least 15 minutes under running water with eyelids held open, consult an eye specialist.
On ingestion:
Immediately rinse mouth and then drink 200-300 ml of water, seek medical attention.
4.2. Most important symptoms and effects, both acute and delayed
Symptoms: The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11., Further symptoms are possible
4.3. Indication of any immediate medical attention and special treatment needed
Treatment: Treat according to symptoms (decontamination, vital functions), no known specific antidote. Pulmonary odema prophylaxis. Medical monitoring for at least 24 hours.
Fire-fighting measures
5.1. Extinguishing media
Suitable extinguishing media:
water spray, dry powder, alcohol-resistant foam
5.2. Special hazards arising from the substance or mixture
nitrogen oxides, carbon oxides
The substances/groups of substances mentioned can be released in case of fire. Under certain conditions in case of fire other hazardous combustion products may be generated.
5.3. Advice for fire-fighters
Special protective equipment:
Wear a self-contained breathing apparatus.
Further information:
Cool endangered containers with water-spray. Dispose of fire debris and contaminated extinguishing water in accordance with official regulations.
Accidental release measures
6.1. Personal precautions, protective equipment and emergency procedures
Use personal protective clothing. Information regarding personal protective measures see, section 8. Ensure adequate ventilation. Avoid inhalation. Avoid contact with the skin, eyes and clothing.
6.2. Environmental precautions
Do not discharge into drains/surface waters/groundwater.
6.3. Methods and material for containment and cleaning up
For small amounts: Pick up with absorbent material (e.g. sand, sawdust, general-purpose binder).
For large amounts: Pick up with suitable appliance and dispose of.
Wear suitable protective equipment. Collect waste in suitable containers, which can be labeled and sealed. Clean contaminated floors and objects thoroughly with water and detergents, observing environmental regulations. Incinerate or take to a special waste disposal site in accordance with local authority regulations.
6.4. Reference to other sections
Information regarding exposure controls/personal protection and disposal considerations can be found in section 8 and 13.
Handling and storage
7.1. Precautions for safe handling
Ensure thorough ventilation of stores and work areas. Wear suitable gloves and eye/face protection.
Protection against fire and explosion:
Prevent electrostatic charge - sources of ignition should be kept well clear - fire extinguishers should be kept handy.
7.2. Conditions for safe storage, including any incompatibilities
Segregate from acids and acid forming substances.
Suitable materials for containers: Low density polyethylene (LDPE), Stainless steel 1.4301 (V2), Stainless steel 1.4401, glass, High density polyethylene (HDPE), Aluminium
Unsuitable materials for containers: Galvanized carbon steel (Zinc), Paper/Fibreboard, Carbon steel (Iron)
Further information on storage conditions: Containers should be stored tightly sealed in a dry place.
Storage class according to TRGS 510 (originally VCI, Germany): (10) Combustible liquids
Storage stability:
Storage temperature: 20 °C
Storage duration: 12 Months
May yellow after lengthy storage.
From the data on storage duration in this safety data sheet no agreed statement regarding the warrantee of application properties can be deduced.
7.3. Specific end use(s)
For the relevant identified use(s) listed in Section 1 the advice mentioned in this section 7 is to be observed.
Transport information
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Marine transport (UN RTDG/IMDG)
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Exposure controls / personal protection
8.1. Control parameters
Components with occupational exposure limits
The surveillance of the workplace by exposure measurements may be necessary, in order to proof the efficiency of safety measures, for example ventilation or the need of respiratory protection. Since this requires a specific competency, only accredited laboratories should be contracted. Regarding suitable methods to assess inhalative exposure the European Standards EN 482, 689 and 14042 are to be considered. In addition the TRGS 402 has to be observed in Germany.
110-85-0: Piperazine
TWA value 0,1 mg/m3 (OEL (EU))
indicative
STEL value 0,3 mg/m3 (OEL (EU))
indicative
OEL 0,1 mg/m3 (TRGS 900 (DE)), Vapor and aerosol
Ceiling limit value/factor: 1
corrosive, toxic
Short Term Exposure Classification: (TRGS 900 (DE)), Vapor and aerosol
Category I: Substances for which the localized effect has an assigned exposure limit or for substances with a sensitizing effect in respiratory passages
PNEC
freshwater: 0,1 mg/l
marine water: 0,01 mg/l
intermittent release: 1 mg/l
STP: 18,08 mg/l
sediment (freshwater): 0,52 mg/kg
sediment (marine water): 0,052 mg/kg
soil: 0,452 mg/kg
oral (secondary poisoning):
No PNEC oral derived, as accumulation in organisms is not to be expected.
DNEL
No DNELs have been derived.
8.2. Exposure controls
Personal protective equipment
Respiratory protection:
Respiratory protection in case of vapour/aerosol release. Gas filter for gases/vapours of organic compounds (boiling point >65 °C, e. g. EN 14387 Type A)
Hand protection:
Chemical resistant protective gloves (EN 374)
Suitable materials also with prolonged, direct contact (Recommended: Protective index 6, corresponding > 480 minutes of permeation time according to EN 374):
e.g. nitrile rubber (0.4 mm), chloroprene rubber (0.5 mm), polyvinylchloride (0.7 mm) and other
Manufacturer's directions for use should be observed because of great diversity of types.
Supplementary note: The specifications are based on tests, literature data and information of glove manufacturers or are derived from similar substances by analogy. Due to many conditions (e.g. temperature) it must be considered, that the practical usage of a chemical-protective glove in practice may be much shorter than the permeation time determined through testing.
Eye protection:
Tightly fitting safety goggles (splash goggles) (e.g. EN 166)
Body protection:
Body protection must be chosen depending on activity and possible exposure, e.g. apron, protecting boots, chemical-protection suit (according to EN 14605 in case of splashes or EN ISO 13982 in case of dust).
General safety and hygiene measures
Handle in accordance with good industrial hygiene and safety practice. Wearing of closed work clothing is required additionally to the stated personal protection equipment. Avoid contact with the skin, eyes and clothing. Do not breathe vapour/spray. Where there is any possibility that the eyes of an employee may be exposed to this substance, the employer should provide an eye wash fountain within the immediate working area for emergency use. Take off immediately all contaminated clothing. Store work clothing separately. No eating, drinking, smoking or tobacco use at the place of work. Hands and/or face should be washed before breaks and at the end of the shift. Gloves must be inspected regularly and prior to each use. Replace if necessary (e.g. pinhole leaks).
Stability and reactivity
10.1. Reactivity
No hazardous reactions if stored and handled as prescribed/indicated.
Formation of flammable gases: Remarks: Forms no flammable gases in the presence of water.
10.2. Chemical stability
The product is stable if stored and handled as prescribed/indicated.
10.3. Possibility of hazardous reactions
Strong exothermic reaction with acids.
10.4. Conditions to avoid
Avoid extreme temperatures. See MSDS section 7 - Handling and storage.
10.5. Incompatible materials
Substances to avoid:
acids, acid forming substances, nitrosating agents
10.6. Hazardous decomposition products
Thermal decomposition products:
carbon oxides, nitrogen oxides
Disposal considerations
13.1. Waste treatment methods
Incinerate in suitable incineration plant, observing local authority regulations.
A waste code in accordance with the European waste catalog (EWC) cannot be specified, due to dependence on the usage.
The waste code in accordance with the European waste catalog (EWC) must be specified in cooperation with disposal agency/manufacturer/authorities.
Contaminated packaging:
Contaminated packaging should be emptied as far as possible; then it can be passed on for recycling after being thoroughly cleaned.
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