Registration Dossier
Registration Dossier
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EC number: 203-142-3 | CAS number: 103-76-4
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
With high probability acutely not harmful to aquatic invertebrates.
Key value for chemical safety assessment
Additional information
QSAR-disclaimer
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
For the assessment ofhydroxyethylpiperazine (CAS 103 -76 -4) (Q)SAR results were used for short-term toxicity to aquatic invertebrates.The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.
Therefore, further experimental studies on short-term toxicity to aquatic invertebrates are not provided.
Assessment
The acute effects of hydroxyethylpiperazine (CAS 103 -76 -4) to aquatic invertebrates are assessed in a weight-of-evidence approach using QSAR data. Only those results were considered where the substance was in the applicability domain of the model. The following QSAR models were used to derive an acute E(L)C50:
- QSAR Toolbox v4.4: Branchiopoda E(L)C50 (48 h): 256 mg/L
- US EPA T.E.S.T. v4.2.1: Daphnia magna LC50 (48 h): 295 mg/L
- EPI Suite v4.11 - ECOSAR v1.11: Aliphatic amines: Daphnid LC50 (48 h): 379 mg/L
It can be concluded that the substance is with high probability acutely not harmful to aquatic invertebrates.
For evaluation purposes an EC50 of 256 mg/L is used in a worst-case approach.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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