Octafluoropropane

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

read-across based on grouping of substances (category approach)

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Justification for type of information:

Perfluorocarbons form a class of compounds with very similar propertioes with regards to living systems. They have been used in numerous medical applications, and so various studies have been performed by other parties and these have established how the materials behave

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1979

Report date:

1979

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Version / remarks:

Predates 403, but methodology is comparable.

GLP compliance:

not specified

Test type:

traditional method

Test material

Test material information

Constituent 1

Reference substance name:

Perflunafene

EC Number:

206-192-4

EC Name:

Perflunafene

Cas Number:

306-94-5

Molecular formula:

C10F18

IUPAC Name:

1,1,2,2,3,3,4,4,4a,5,5,6,6,7,7,8,8,8a-Octadecafluoronaphthalene

Test material form:

other: vapour

Test animals

Species:

rat

Strain:

other: Charles River CD

Sex:

male/female

Details on test animals or test system and environmental conditions:

Houses in plastic cages, free food and water (fasting overnight prior to expusure), observed for 1 week prior, kept in air conditioned room at 70-80°F 40-60% humidity.

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

head only

Vehicle:

air

Analytical verification of test atmosphere concentrations:

yes

Remarks:

GC

Duration of exposure:

ca. 60 min

Concentrations:

8647 ppm (i.e., vapour pressure concentration)

No. of animals per sex per dose:

5 male, 5 female

Control animals:

no

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 8 647 ppm

Based on:

test mat.

Exp. duration:

60 min

Mortality:

None

Clinical signs:

other: None

Body weight:

Not altered

Gross pathology:

Nothing attributed to test material

Any other information on results incl. tables

"PFD exposure did not produce any toxic sign in rats during or after exposure. Body weights were not altered by exposure. ..."

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information Criteria used for interpretation of results: expert judgment

Conclusions:

"No toxicity could be demonstrated after exposure to 8647 ppm of perfluorodecalin."

Executive summary:

"No toxicity could be demonstrated after exposure to 8647 ppm of perfluorodecalin."