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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1975
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Brief summary report in German. Only a very short description is reported. However, dose, number of animals and observation period are critical points which are mentioned in the study.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1975

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
No guideline followed
GLP compliance:
no
Remarks:
not present at the time of performance.
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Reaction mass of 2-[7-isopropyl-5-methylbicyclo[2.2.2]oct-5-en-2-yl]-1,3-dioxolane and 2-[8-isopropyl-6-methylbicyclo[2.2.2]oct-5-en-2-yl]-1,3-dioxolane
EC Number:
916-737-4
Molecular formula:
Reaction mass of 2-[7-isopropyl-5-methylbicyclo[2.2.2]oct-5-en-2-yl]-1,3-dioxolane and 2-[8-isopropyl-6-methylbicyclo[2.2.2]oct-5-en-2-yl]-1,3-dioxolane
IUPAC Name:
Reaction mass of 2-[7-isopropyl-5-methylbicyclo[2.2.2]oct-5-en-2-yl]-1,3-dioxolane and 2-[8-isopropyl-6-methylbicyclo[2.2.2]oct-5-en-2-yl]-1,3-dioxolane
Test material form:
not specified
Details on test material:
- Name of test material (as cited in study report): Glycolierral

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Füllinsdorfer Zucht
- Weight at study initiation: 70 - 100 g
- Fasting period before study: no data
- Housing: no data
- Diet (e.g. ad libitum): no data
- Water (e.g. ad libitum): no data
- Acclimation period: no data

ENVIRONMENTAL CONDITIONS
No data.

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data.
Doses:
4000, 8000 mg/kg
No. of animals per sex per dose:
4/dose in total
Control animals:
no
Details on study design:
- Duration of observation period following administration: 10 days
- Frequency of observations and weighing: no data.
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs
Statistics:
No data.

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 8 000 mg/kg bw
Based on:
test mat.
95% CL:
> 8 000
Mortality:
No deaths occurred.
Clinical signs:
Sedation, respiratory depression, after 24 hours slightly sedated, after 48 hours o.B.
Body weight:
No data.
Gross pathology:
No data.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
In an acute oral toxicity with rats, an LD50 >8000 mg/kg bw was determined.
Executive summary:

Glycolierral was tested in an acute oral toxicity study with rats. No deaths occurred. Sedation and respiratory depression were observed among the animals.

Based on the results, an LD50 >8000 mg/kg bodyweight was determined.