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Diss Factsheets
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EC number: 943-533-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study, to GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 2001
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Reaction mass of 6-ethyl-3-methyloct-5-en-1-ol and 6-ethyl-3-methyloct-6-en-1-ol
- Molecular formula:
- C11H22O
- IUPAC Name:
- Reaction mass of 6-ethyl-3-methyloct-5-en-1-ol and 6-ethyl-3-methyloct-6-en-1-ol
- Test material form:
- other: liquid
- Details on test material:
- Identification: Super Muguet
Description: Clourless to pale yellow liquid
Batch Number: 9000408259
Purity: 99.9%
Stability of test item: Stable under storage conditions
Expiry date: 08-12-2002
Storage Conditions: In the original container, at room temperature (range 17-23 °C), away from direct sunlight.
Safety Precautions: Routine hygenic procudures were used to ensure the health and safety of the personnel.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Test system: New Zealand White Rabbit, SPF
Rationale: Recognized by the international guidelines as the recommended test system
Source: Elevage Scientifique des Dombes F-01400 Chatillon sur Chalaronne / France
Number of animals per test: 3 (Animals of both sexes were used)
Ages at start of treatment: 12-13 weeks (male), 10-11 weeks (female)
Body weights at start of treatment: 2.1-2.3 kg
Identification: By unique cage number and corresponding ear number
Acclimatization: Under laboratory conditions after health examination. Only animals without any visual signs of illness were used for the study.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 mL per animal
- Duration of treatment / exposure:
- The duration of treatment was 4 hours.
- Observation period:
- The scoring of the skin reactions was performed 1, 24, 48 and 72 hours, as well as 7, 10 and 14 days after removal of the dressing.
- Number of animals:
- 3 animals per test
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- mean
- Basis:
- animal #1
- Time point:
- other: mean: 24, 48 and 72 hours
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- no data
- Irritation parameter:
- erythema score
- Remarks:
- mean
- Basis:
- animal #2
- Time point:
- other: Mean: 24, 48 and 72 hours
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- no data
- Irritation parameter:
- erythema score
- Remarks:
- mean
- Basis:
- animal #3
- Time point:
- other: Mean: 24, 48 and 72 hours
- Score:
- 1.67
- Max. score:
- 4
- Reversibility:
- no data
- Irritation parameter:
- edema score
- Remarks:
- mean
- Basis:
- animal #1
- Time point:
- other: Mean: 24, 48 and 72 hours
- Score:
- 1.33
- Max. score:
- 4
- Reversibility:
- no data
- Irritation parameter:
- edema score
- Remarks:
- mean
- Basis:
- animal #2
- Time point:
- other: Mean: 24, 48 and 72 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- no data
- Irritation parameter:
- edema score
- Remarks:
- mean
- Basis:
- animal #3
- Time point:
- other: Mean: 24, 48 and 72 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- no data
- Irritant / corrosive response data:
- The mean score was calculated across 3 scoring times ( 24, 48 and 72 hours after patch removal) for each animal for eryherma/eschar grades and for oedema grades, separately. The mean eryherma/eschar score of the three animals was 2.00, 2.00 amd 1.67, respectively and the mean oedema score was 1.33, 1.00 and 1.00, respectively.
Well-defined erythema was observed in all animals 1 hour after treatment and persisted in two animals up to the 72-hour reading and in the other animal up to 48-hour reading. In addition, very slight erythema was evident in one animal at the 72-hour reading and in the other two animals at both the 7- and 10- day readings.
Very slight to slight swelling was noted at the test site of all animals from 1 to 72 hours after treatment.
Scaling was first observed at the test site of one animal 72 hours after treatment and in the other two animals 7 das after treatment. This finding was still present on all animals on test day 14 at termination. - Other effects:
- No staining by the test item of the treated skin was observed.
No irreversible alterations of the treated skin were observed nor were corrosive effects evident on the skin.
Applicant's summary and conclusion
- Interpretation of results:
- other: Irritation observed, but not sufficient for classification.
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- .
- Executive summary:
In an in vivo study, conducted to GLP, according to the OECD Guideline 404, undiluted Super Muguet (0.5 mL) was applied to the skin of 3 New Zealand White Rabbits for 4 hours.
The mean score was calculated across 3 scoring times ( 24, 48 and 72 hours after patch removal) for each animal for eryherma/eschar grades and for oedema grades, separately. The mean eryherma/eschar score of the three animals was 2.00, 2.00 amd 1.67, respectively and the mean oedema score was 1.33, 1.00 and 1.00, respectively.
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