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Diss Factsheets
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EC number: 943-533-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study, to GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 6-ethyl-3-methyloct-5-en-1-ol
- EC Number:
- 247-615-2
- EC Name:
- 6-ethyl-3-methyloct-5-en-1-ol
- Cas Number:
- 26330-64-3
- Molecular formula:
- C11H22O
- IUPAC Name:
- 6-ethyl-3-methyloct-5-en-1-ol
- Reference substance name:
- 247-615-2 & 247-616-8
- IUPAC Name:
- 247-615-2 & 247-616-8
- Test material form:
- other: liquid
- Details on test material:
- Test article identification: Super Muguet
Batch number: SC00011582
CAS Number: 26330-64-3
EC number: 247-615-2 & 247-616-8
Molecular formula: C11H22O
Molecular weight: 170.30 g/mol
Expiration date: 20 June, 2016
Appearance: Clear, colourless liquid
Purity: 98.27 %
Storage conditions: Sealed container, 15 to 30 deg C, in the dark
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Female (nulliparous, non-pregnant) Crl:WI(Han) strain rats were obtained from Charles River UK Ltd., Margate. All animals were given a clinical inspection for ill health on arrival and a sample was weighed.
Rats were arbitrarily selected from the delivery boxes and allocated to the appropriate number of cages using a sequence that reduced selective bias. The condition of the animals was assessewd daily throughout the acclimatisation period of 14 to 16 days. A second inspection was performed prior to the study commencement to ensure the animals were suitable for the study. Overtly healthy animals were arbitrarily allocated study groups at least one day prior to dosing.
At the start of the study the rats were 9 to 10 weeks of ages. The weight variation did not exceed ± 20% of the mean weight.
- Housing: The animals were housed in groups of up to 5 during the acclumatisation period in cages that conform to the 'Code of Practice for the Housing and Care of Animals Used in Scientific Procedures' (Home Office, London, 1989). From the day prior to dosing (Day -1), the rats were housed in groups of 3 in similar cages.
Bedding was provided on a weekly basis to each cage by use of clean European sofe wood bedding (Datesand Ltd, Manchester, UK).
Each atch of bedding was analysed for specific constituents and contaminants. No contaminants werre present in the bedding at levels which might have interfered with achieving the objective of the study.
- Water: Mains water was provided ad libitum via cage mounted water bottles. Yje water was periodically analysed for specific contaminants.
No contaminants were present in the water at levels which mighthave interfered with achieving the objective of the goal.
- Diet: Throughout the study the animals had access to SQC(E) Rat and Mouse Maintenance Diet No. 1, from Special Diets Services Ltd., Witham, UK which was freely available to the animals at all times, except for a period of fasting from the evening of the day prior to dosing (Day -1) until approximately 3 hours after dosing. Each batch of diet had been analysed for specific constituents and contaminants. No contaminants werre present in the bedding at levels which might have interfered with achieving the objective of the study.
- Environment: The animal rooms were designed to permit 15 to 20 air changes per hour. The target temperature and humidity were 20 to 24 °C and 45 to 65% respectively. Daily recordings of maximum and minimum temperature and humidity were made.
Fluorescent lighting was controlled automatically to give a cycle of 12 hours light and 12 hours dark.
- Environmental Enrichment: In order to enrich both the environment and the welfare of the animals, they were provided with wooden Aspen chew blocks and rodent retreats.
- Animal Identification: A number written on the tail in indelible ink on the day before dosing individually identified the rats. A colour coded card on each cage gave information including study number, group number, animal numbers and sex.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- The test article was used as supplied. The specific gravity was determined and used to calculate the appropriate does volume for the required does level. Dose containers were repeatedly inverted prior to the administration to ensure homogeneity.
- Doses:
- A limit test at one dose level of 2000 mg/kg was carried out with six animals (three animals per step).
- No. of animals per sex per dose:
- Six
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There were no deaths.
- Clinical signs:
- other: No clinical signs were seen.
- Gross pathology:
- No abnormalities were noted at necropsy of animals killed at the end of the study.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- The acute median lethal oral dose level of the test article, Super Muguet, was found to exceed 2000 mg/kg.
The test material was considered to have no significant acute toxic risk in respect of its acute oral toxicity and did not meet the criterea for classification according to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS).
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