Registration Dossier
Registration Dossier
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EC number: 248-451-4 | CAS number: 27425-55-4
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Toxikologische Untersuchung einiger in der ungarischen Industrie zur Anwendung gelangenden aromatischen Amidoverbindungen
- Author:
- Sziza, M. and Podhragyai, L.
- Year:
- 1 957
- Bibliographic source:
- Archiv fuer Gewerbepathologie und Gewerbehygiene 15, 447-456 (1957)
- Reference Type:
- other: Authoritative data base
- Title:
- GCID 512735
- Author:
- ACToR Database
- Year:
- 2 011
- Bibliographic source:
- ACToR (Aggregated Computational Toxicology Resource):- Sziza, M. and Podhragyai, L.: Archiv fuer Gewerbepathologie und Gewerbehygiene 15, 447-456 (1957)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Induction exposure by dermal application of a 10 % solution of N,N-diethylaniline; challenge exposure by dermal application of 1 or 2 % solutions of the test substance
- GLP compliance:
- not specified
- Type of study:
- not specified
Test material
- Reference substance name:
- N,N-diethylaniline
- EC Number:
- 202-088-8
- EC Name:
- N,N-diethylaniline
- Cas Number:
- 91-66-7
- IUPAC Name:
- N,N-diethylaniline
- Details on test material:
- - Name of test material: N,N-diethylaniline
- Substance type: Organic
- Physical state: Liquid
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- other: Dermal
- Vehicle:
- other: Acetone
- Concentration / amount:
- 10% (induction) and 1 or 2 % (challenge)
Challengeopen allclose all
- Route:
- other: Dermal
- Vehicle:
- other: Acetone
- Concentration / amount:
- 10% (induction) and 1 or 2 % (challenge)
- No. of animals per dose:
- no data
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Group:
- test chemical
- Dose level:
- 10% (induction) and 1 or 2 % (challenge)
- Clinical observations:
- Not Sensitizing
- Remarks on result:
- other: Reading: 1st reading. Group: test group. Dose level: 10% (induction) and 1 or 2 % (challenge). Clinical observations: Not Sensitizing.
Any other information on results incl. tables
Not Sensitizing
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- No sensitization was reported from the Induction exposure by dermal application of a 10 % solution of N,N-diethylaniline; and challenge exposure by dermal application of 1 or 2 % solutions of N,N-diethylaniline
- Executive summary:
No sensitization was reported from the Induction exposure by dermal application of a 10 % solution of N,N-diethylaniline; and challenge exposure by dermal application of 1 or 2 % solutions of N,N-diethylaniline
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