Registration Dossier
Registration Dossier
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EC number: 210-478-4 | CAS number: 616-38-6
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: peer-reviewed data
Data source
Referenceopen allclose all
- Reference Type:
- other: database
- Title:
- Dimethyl Carbonate [CAS 616-38-6, HSDB number 6928]
- Author:
- HSDB (Hazardous Substances Database), U.S. National Library of Medicine
- Year:
- 2 003
- Bibliographic source:
- http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp/~3O9KQg:1
- Reference Type:
- secondary source
- Title:
- Esters of Carbonic and Orthocarbonic Acid, Organic Phosphorous, Monocarboxylic Halogenated Acids, Haloalcohols, and Organic Silicon
- Author:
- Michael S. Bisesi, Ph.D., CIH
- Year:
- 2 001
- Bibliographic source:
- J. J. Clary, V. J. Feron, and J. A. van Velthuijsen, Safety assessment of lacate esters. Regul. Toxicol. Pharmacol. 27, 88–97 (1998); cited in: Patty's Toxicology (5th Edition) Volumes 1-8; Volume 6, John Wiley & Sons
- Reference Type:
- publication
- Title:
- no data
- Author:
- unknown
- Year:
- 1 979
- Bibliographic source:
- FCTXAV Food and Cosmetics Toxicology, London, UK V.1-19, 1963-81; for publisher information, see : FCTOD7 Food and Chemical Toxicology, Volume 17, page 361, 1979
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: no data
- Deviations:
- not specified
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Dimethyl carbonate
- EC Number:
- 210-478-4
- EC Name:
- Dimethyl carbonate
- Cas Number:
- 616-38-6
- Molecular formula:
- C3H6O3
- IUPAC Name:
- dimethyl carbonate
Constituent 1
Test animals
- Species:
- other: mouse and rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- unchanged (no vehicle)
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 800 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: LD50 (mouse)
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 600 mg/kg bw
- Remarks on result:
- other: LD50 (rat)
Applicant's summary and conclusion
- Conclusions:
- The undiluted dimethyl carbonate liquid has an intraperitoneal LD50 in the mouse and the rat in the range of 800 to 1600 mg/kg bw.
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