Registration Dossier
Registration Dossier
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EC number: 210-478-4 | CAS number: 616-38-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: peer-reviewed literature
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Esters of Carbonic and Orthocarbonic Acid, Organic Phosphorous, Monocarboxylic Halogenated Acids, Haloalcohols, and Organic Silicon
- Author:
- Michael S. Bisesi, Ph.D., CIH
- Year:
- 2 001
- Bibliographic source:
- J. J. Clary, V. J. Feron, and J. A. van Velthuijsen, Safety assessment of lacate esters. Regul. Toxicol. Pharmacol. 27, 88–97 (1998); cited in: Patty's Toxicology (5th Edition) Volumes 1-8; Volume 6, John Wiley & Sons
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: no data
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- other: no data
- Limit test:
- no
Test material
- Reference substance name:
- Dimethyl carbonate
- EC Number:
- 210-478-4
- EC Name:
- Dimethyl carbonate
- Cas Number:
- 616-38-6
- Molecular formula:
- C3H6O3
- IUPAC Name:
- dimethyl carbonate
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- no data
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 10 mL/kg bw
- Based on:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 10 600 mg/kg bw
- Based on:
- not specified
- Remarks on result:
- other: "recalculated" (with density = 1.06 g/mL)
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- A dermal LD50 in the guinea pig was found to be greater than 10 mL/kg bw (=10.6 g/kg bw). Some weight loss was noted, and minimal skin absorption was suspected. However, the degree of irritation was relatively slight.
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