Registration Dossier
Registration Dossier
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EC number: 217-090-4 | CAS number: 1738-25-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Publication which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data : List VI
- Author:
- Smyth Jr. H.F., Carpenter C.P., Weil C.S., Pozzani U.C., Striegel J.A., Striegel B.S.
- Year:
- 1 962
- Bibliographic source:
- Am. Ind. Hyg. Assoc. J. 23, 95-107
Materials and methods
- Principles of method if other than guideline:
- Penetration of rabbit skin is estimated by a technique closely akin to the one-day, cuff Method of Draize et al. (1944).
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3-dimethylaminopropiononitrile
- EC Number:
- 217-090-4
- EC Name:
- 3-dimethylaminopropiononitrile
- Cas Number:
- 1738-25-6
- Molecular formula:
- C5H10N2
- IUPAC Name:
- 3-(dimethylamino)propanenitrile
- Details on test material:
- 3-Dimethylaminopropionitrile, no further data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): not specified - Duration of exposure:
- 24 h
- Doses:
- no data
- No. of animals per sex per dose:
- 4 males
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 213 mg/kg bw
- Remarks on result:
- other: original LD50 value: 1410 (880 - 2290) µL/kg bw (calculated with a density of 0.86 g/mL)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
