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Diss Factsheets
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EC number: 240-032-4 | CAS number: 15894-70-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No reliable long-term toxicity data are available for the toxicity of HMBDA to fish. However, a waiver is applied for this endpoint.
Key value for chemical safety assessment
Additional information
No reliable long-term toxicity data are available for the toxicity of HMBDA to fish. However, a waiver is applied for this endpoint.
Under Column 2 of the Annex IX of Regulation (EC) No 1907/2006 the specific rules for adaptation from Column 1 are that the long-term toxicity testing shall be proposed by the registrant if the chemical safety assessment according to Annex I indicates the need to investigate further the effects on fish. It is proposed that testing is waived as exposure potential is minimal as substance is an intermediate product and manufactured and utilized only at one location in the EU and handled under strictly controlled conditions. The substance’s low hydrophilicity is demonstrated by the very low octanol-water partition coefficient (Log Kow) of 0.465 at a neutral pH. The low log Kow indicates the substance has a low adsorptive and bioaccumulative potential.
The short-term fish studies reported in this assessment provide evidence of the low toxicity to fish with lethal concentrations (LC50) greater than 13 mg/L. Mean measured concentrations of HMBDA at test initiation and test end ranged from 13-30 percent of nominal demonstrating the very low solubility and that it is impractical to carry out long-term toxicity testing with sparingly soluble substances.
Additionally, aquatic toxicity studies (Harland 1998), provided in Section 6.6 of this dossier, have been conducted on the wastewater effluent from the one facility where the substance is in use. Such effluent toxicity studies were used to determine the maximum effluent release rate where no acute toxicity to fish would occur and no chronic effects to fish would occur at the edge of the mixing zone. Study results indicate that maximum effluent release rates are a magnitude higher than the desirable release rate. Therefore, under such conditions and due to low solubility, minimal exposure to aquatic organisms and no adverse effects to fish are expected. Therefore, no further testing is needed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.