1-methyl-2-pyrrolidone

Health surveillance data

Administrative data

Endpoint:

health surveillance data

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

publication

Title:

Biological monitoring and health effects of low-level exposure to N-methyl-2-pyrrolidone: a cross-sectional study

Author:

Haufroid V., Jaeger V.K., Jeggi S., Eisenegger R., Bernard A., Friedli D., Lison D. and Hotz P.

Year:

2014

Bibliographic source:

Int Arch Occup Environ Health 87: 663-674

Materials and methods

Study type:

medical monitoring

Remarks:

Biomonitoring

Endpoint addressed:

basic toxicokinetics

Test guideline

Qualifier:

no guideline followed

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

1-methyl-2-pyrrolidone

EC Number:

212-828-1

EC Name:

1-methyl-2-pyrrolidone

Cas Number:

872-50-4

Molecular formula:

C5H9NO

IUPAC Name:

1-methylpyrrolidin-2-one

Test material form:

liquid

Method

Type of population:

occupational

Ethical approval:

not specified

Details on study design:

A cross-sectional study was carried out between 2006 and 2011 in northeast Switzerland including 21 firms representing a large spectrum of activities and 91 workers exposed to NMP. The external and internal exposure to NMP was investigated. Airborne NMP was collected by personal sampling over a whole workday. Urinary 5-HNMP and 2-HMSI were examined for assessing an occupational exposure to NMP and to look for health effects. A group of workers exposed only to organic solvents but not to NMP was included to increase the ability to detect possible differences, if any, in outcomes between NMP and other solvents.

Results and discussion

Results:

Urinary metabolites correlated very well with the airborne NMP concentrations, although these concentrations were low. At the low levels found in this study, no irritation, renal, haematological or neurobiological effects could be found.

Any other information on results incl. tables

Table 1: Airborne NMP and urinary metabolites

	Non-exposed workers (n=114)	Exposed workers (n=91)
Airborn NMP (mg/m³)	0.01 (0.002-0.40)	0.18 (0.002-6.99)
Airborne NMP not detectable (n, %)	38 (34)	8 (9)
Urinary metabolites (mg/L)
End of shift
5-HNMP	0.10 (0.10-0.80)	0.60 (0.10-29.00)
2-HMSBI	0.30 (0.10-1.50)	0.80 (0.20-23.30)
Before shift
5-HNMP	0.10 (0.10-0.60)	0.45 (0.10-22.90)
2-HMSI	0.30 (0.10-2.40)	1.55 (0.10-58.00)
Urinary metabolites (mg/g creatinine)
End of shift
5-HNMP	0.09 (0.04-0.60)	0.39 (0.05-41.41)
2-HMSI	0.23 (0.07-1.04)	0.56 (0.11-19.89)
Before shift
5-HNMP	0.06 (0.04-0.32)	0.27 (0.04-10.51)
2-HMSI	0.20 (0.06-1.39)	1.06 (0.09-42.89)
Humidity (%)	50.2 (25.9-66.9)	51.0 (30.5-72.0)
Temperature (°C)	20.7 (10.2-26.4)	20.3 (1.0-24.3)