Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin sensitisation: in vivo (LLNA)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Review article data are considered to be from a trusted source

Data source

Reference
Reference Type:
review article or handbook
Title:
Comparison of the skin sensitizing potential of unsaturated compounds as assessed by murine local nymph node assay (LLNA) and the guinea pig maximization test (GPMT)
Author:
R. Kreiling, H.M. Hollnagel, L. Hareng, M.S. Lee, P. Griem, B. Dreeßen, M. Kleber, A. Albrecht, C. Garcia, A. Wendel
Year:
2008
Bibliographic source:
Food and Chemical Toxicology, Vol. 46, Issue 6, p. 1896-1904

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
GLP compliance:
not specified
Type of study:
mouse local lymph node assay (LLNA)

Test material

Constituent 1
Chemical structure
Reference substance name:
Maleic acid
EC Number:
203-742-5
EC Name:
Maleic acid
Cas Number:
110-16-7
Molecular formula:
C4H4O4
IUPAC Name:
but-2-enedioic acid

Results and discussion

In vivo (LLNA)

Results
Parameter:
SI
Remarks on result:
other: 16.1+/-6.3

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Remarks:
Migrated information