Registration Dossier
Registration Dossier
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EC number: 201-178-4 | CAS number: 79-11-8
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 01 March - 10 April 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- no
- Remarks:
- did not exist at that time
Test material
- Reference substance name:
- Chloroacetic acid
- EC Number:
- 201-178-4
- EC Name:
- Chloroacetic acid
- Cas Number:
- 79-11-8
- Molecular formula:
- C2H3ClO2
- IUPAC Name:
- chloroacetic acid
- Details on test material:
- monochloressigsaure VA 2308
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- other: 0.9% saline
- Details on exposure:
- subcutaneous
- Doses:
- 80, 100, 125, 200, 315 mg/kg
- No. of animals per sex per dose:
- 10 females per dose group
- Control animals:
- no
- Details on study design:
- not specified
- Statistics:
- probit analysis (method after Linder and Weber)
95%CL according to Cavelli-Sforza
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- ca. 97.4
- Based on:
- test mat.
- 95% CL:
- 89.9 - 105.5
- Mortality:
- 80 mg/kg 1/10
100 mg/kg 5/10
125 mg/kg 10/10
200 mg/kg 10/10
315 mg/kg 10/10 - Clinical signs:
- hunched posture, piloerection, ptosis, lethargy, uncoordinated movements, tremor, salivation, quick breathing, laboured breathing
- Body weight:
- no data
- Gross pathology:
- Brown discoloration of the liver and strong vasculated liver, red jejunum.
Treatment area grey-brown discoloration of the dermis and muscle.
Applicant's summary and conclusion
- Conclusions:
- LD50 97.4 mg/kg in females
95%CL 89.9-105.5 mg/kg
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