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EC number: 203-419-9 | CAS number: 106-65-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Nasal lesion develpoment and reversibility in rats exposed to aerosols of dibasic esters
- Author:
- Lee K-P, Valentine R, Bogdanffy M S.
- Year:
- 1 992
- Bibliographic source:
- Toxicologic Pathology 20(3): 376-393, 1992
Materials and methods
- Principles of method if other than guideline:
- 4 hour exposure to a single concentration. Groups of exposed aninals killed 1, 4, 7, 14, 21 and 42 days post-exposure for assessment of nasal lesions
- GLP compliance:
- not specified
- Test type:
- other: Assessment of nasal tolerance
- Limit test:
- yes
Test material
- Reference substance name:
- Dibasic esters
- IUPAC Name:
- Dibasic esters
- Details on test material:
- - Name of test material (as cited in study report): Dibasic esters
- Substance type: Mixture
- Physical state: Liquid
- Composition of test material, percentage of components: 66.0% dimethylglutarate; 16.5% dimethylsuccinate; 17.0% dimethyl adipate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories, Raleigh, NC
- Age at study initiation: 7 weeks
- Housing: Indiviually caged
- Diet (e.g. ad libitum): Purina Rat Chow, ad-libitum except during exposure
- Water (e.g. ad libitum): Ad-libitum except during exposure
- Acclimation period: 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 - 25 deg C
- Humidity (%): 40 - 60%
- Air changes (per hr):
- Photoperiod (hrs dark / hrs light): 2 hours light / 12 hours dark
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- clean air
- Mass median aerodynamic diameter (MMAD):
- 3.9 µm
- Geometric standard deviation (GSD):
- 1.6
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure chamber volume: 150 L
- Method of holding animals in test chamber: Restraint tubes
- Source and rate of air: Ambient air, 20 L / minute
- Method of conditioning air: Filtration
- System of generating particulates/aerosols: Airlite H2500 Solo-Sphere Nebuliser
- Method of particle size determination: Sierra Series 210 cascade impactor with constant air flow sampling pump
- Treatment of exhaust air: Tandem dry ice cold traps and an MSA-activated charcoal/HEPA filter
- Temperature, humidity, pressure in air chamber: Temperature: 21.3 - 23.3 deg C; oxygen concentration: 20.4 - 20.9 %
TEST ATMOSPHERE
- Brief description of analytical method used: Gravimetrically from a glass fibre filter trap
- Samples taken from breathing zone: yes
TEST ATMOSPHERE (if not tabulated)
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): 3.9 micron / 1.6 micron - Duration of exposure:
- 4 h
- Concentrations:
- 5900 mg / m3
- No. of animals per sex per dose:
- 42 rats exposed, 7 killed 1, 4, 7, 14, 21 and 42 days post exposure
- Control animals:
- yes
- Details on study design:
- In an investiagtion of nasal tissue damage, morphogenesis and reversibility of lesions induced by dibasic esters, a mixture containing dimethyl succinate together with dimethyl adipate and dimethyl glutarate, male rats were exposed to a mixture concentration of 5900 mg/m3 (5.9 mg/L) for 4 hours. A control group of 24 rats were exposed to air only under the same conditions
Groups of 7 treated and 4 control animals were killed 1, 4, 7, 14, 21 and 42 days post-exposure and subjected to detailed microscopic examination of the nasal tissues.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC0
- Effect level:
- >= 5 900 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- None
Applicant's summary and conclusion
- Conclusions:
- The tested substance, a mixture of dibasic esters containing 16.5% dimethylsuccinate, was not toxic at a concentration of 5900 mg / m3 following 4 hours inhalation exposure
- Executive summary:
In an investigation of nasal tissue damage, morphogenesis and reversibility of lesions induced by dibasic esters, a mixture containing dimethyl succinate together with dimethyl adipate and dimethyl glutarate, male rats were exposed to a mixture concentration of 5900 mg/m3 (5.9 mg/L) for 4 hours. A control group of 24 rats were exposed to air only under the same conditions Groups of 7 treated and 4 control animals were killed 1, 4, 7, 14, 21 and 42 days post-exposure and subjected to detailed microscopic examination of the nasal tissues.
The tested substance, a mixture of dibasic esters containing 16.5% dimethylsuccinate, was not toxic at a concentration of 5900 mg / m3 (5.9 mg/L) following 4 hours inhalation exposure
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