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EC number: 203-403-1 | CAS number: 106-49-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Bewertung wassergefaehrdender Stoffe im Hinblick auf Lagerung, Umschlag und Transport und Untersuchung zur Abklaerung substanz- und bewertungsmethodenspezifischer Grenzfaelle bei der Bewertung wassergefaehrdender Stoffe.
- Author:
- Trenel J, Kuehn R
- Year:
- 1 982
- Bibliographic source:
- Umweltforschungsplan des Bundesministers des Innern
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 E (Ready biodegradability: Modified OECD Screening Test)
- Principles of method if other than guideline:
- Directive 84/449/EEC, C.3; ISO 7824 (1984) (precursor)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- m-toluidine
- EC Number:
- 203-583-1
- EC Name:
- m-toluidine
- Cas Number:
- 108-44-1
- Molecular formula:
- C7H9N
- IUPAC Name:
- 3-methylaniline
- Details on test material:
- purity not specified
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- other: effluent of predominantly domestic STP
- Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 20 mg/L
- Based on:
- DOC
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- -replicates per concentration: 2
Reference substanceopen allclose all
- Reference substance:
- aniline
- Reference substance:
- other: hydroquinone
Results and discussion
% Degradationopen allclose all
- Parameter:
- % degradation (DOC removal)
- Value:
- 83 - 91
- Sampling time:
- 14 d
- Parameter:
- % degradation (DOC removal)
- Value:
- 91 - 98
- Sampling time:
- 21 d
- Parameter:
- % degradation (DOC removal)
- Value:
- 64 - 84
- Sampling time:
- 28 d
- Details on results:
- degradation of m-toluidine (first run)
7 d: - 24 %
14 d: 91 %
21 d: 98 %
28 d: 84 %
degradation of m-toluidine (second run)
7 d: - 24 %
14 d: 83 %
21 d: 91 %
28 d: 64 %
negative values mean an increase of the DOC in the test system compared to the control, no explanation is given for these findings
BOD5 / COD results
- Results with reference substance:
- - degradation of aniline fulfilled the pass level as 86 +/- 10 % (mean value) were degraded after 14 d
- degradation of hydroquinone showed a greater variability, but observed degradation after 14 d reached the pass level
Any other information on results incl. tables
- The report includes results of a multitude of compounds, whereas only the percentage degradation was reported.
- as only these results were provided, where control samples fulfilled the validity criteria (stated by the authors), results are assumed to reliable
- there is no explanation for the decreasing degradation observed after day 21, nevertheless observed degradation at day 28 exceeds the pass level of 70 % degradation
- 10 d window: no specific information is presented, but as no degradation was observed on day 7 and 91 % and 83 %, respectively were degraded at day 14, the fulfilment of the 10 d window can be assumed
_____________________________________________________________________________________________
A read across between the two isomers, meta- and para-toluidine, with their corresponding environmental classification N; R50 was already accepted by the European commission working group on the classification and labelling of dangerous substances (2001):
p-toluidine (612-024-00-4)
Proposal: N; R50
ECBI/57/98 |
D classification proposals for 9 substances |
ECBI/57/98 Add. 7 |
D environmental classification proposals for substances under agenda point 5.3 and 5.4 |
The proposal for re-classification received from D depends on health concerns.Further they propose a separate entry for p-toluidine, which is now in a common entry together with the meta form.In addition p-toluidinium chloride (EC No 208-740-8) and p-toluidine sulphate (1:1) (EC No 208-741-3) would be included in the same entry as p-toluidine. The D proposal supports the current classification for the environment, N; R50.
Sasked on which isomer the environment data was based. D informed that for the meta-form EC50 (for Daphnia) = 0.75 mg/l and that this had been cross read to the para-form for the classification agreed in the 21st ATP. Industry said that they would appreciate to provide information themselves for environmental endpoints.However the Group agreed that it was acceptable to classify the p-toluidine and its salts on the basis of the m-toluidine data.
Conclusion:The Group agreed to classify p-toluidine, p-toluidinium chloride and p-toluidine sulphate (1:1)with N; R50 accompanied by the S-phrase 61 for environmental concerns.The classification for health effects was still under discussion, but as soon as agreed the complete classification proposal will be sent to DG ENV for inclusion in a future ATP.
p-toluidine (612-024-00-4), p-toluidinium chloride (EC No 208-740-8) and p-toluidine sulphate (1:1) (EC No 208-741-3)
Classification |
Toxicity |
Degradation |
Bioaccumulation |
Escape clause |
N; R50 |
Data |
Readily degradable based on data |
log KOW (calculated) < 3 |
Not relevant |
Applicant's summary and conclusion
- Executive summary:
Testing m-toluidine towards ready biodegradability in a modified OECD screening test, 64 % and 84 % of the test item were degraded after 28 d, respectively (Trenel, 1982). Furthermore, the pass level is reached within hte 10 day window. Thus, the substance can be scored as readily biodegradable.
_____________________________________________________________________________________________
A read across between the two isomers, meta- and para-toluidine, with their corresponding environmental classification N; R50 was already accepted by the European commission working group on the classification and labelling of dangerous substances (2001):
p-toluidine (612-024-00-4)
Proposal: N; R50
ECBI/57/98
D classification proposals for 9 substances
ECBI/57/98 Add. 7
D environmental classification proposals for substances under agenda point 5.3 and 5.4
The proposal for re-classification received from D depends on health concerns.Further they propose a separate entry for p-toluidine, which is now in a common entry together with the meta form.In addition p-toluidinium chloride (EC No 208-740-8) and p-toluidine sulphate (1:1) (EC No 208-741-3) would be included in the same entry as p-toluidine. The D proposal supports the current classification for the environment, N; R50.
S asked on which isomer the environment data was based. D informed that for the meta-form EC50 (for Daphnia) = 0.75 mg/l and that this had been cross read to the para-form for the classification agreed in the 21st ATP. Industry said that they would appreciate to provide information themselves for environmental endpoints.However the Group agreed that it was acceptable to classify the p-toluidine and its salts on the basis of the m-toluidine data.
Conclusion:The Group agreed to classify p-toluidine, p-toluidinium chloride and p-toluidine sulphate (1:1)with N; R50 accompanied by the S-phrase 61 for environmental concerns.The classification for health effects was still under discussion, but as soon as agreed the complete classification proposal will be sent to DG ENV for inclusion in a future ATP.
p-toluidine (612-024-00-4), p-toluidinium chloride (EC No 208-740-8) and p-toluidine sulphate (1:1) (EC No 208-741-3)
Classification
Toxicity
Degradation
Bioaccumulation
Escape clause
N; R50
Data
Readily degradable based on data
log KOW (calculated) < 3
Not relevant
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