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Diss Factsheets
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EC number: 932-121-8 | CAS number: 1147459-12-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.3 µg/L
- Assessment factor:
- 50
- PNEC freshwater (intermittent releases):
- 0.86 µg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.03 µg/L
- Assessment factor:
- 500
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 0.2 mg/L
- Assessment factor:
- 10
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 1.981 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.198 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 9.1 mg/kg soil dw
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
All endpoints are based on measured data applying assessment factors.
The PNECaquatic bulkis calculated using the assessment factor proposed by the TGD. As long-term NOECs from species representing two trophic levels are available (algae and daphnia) an assessment factor of 50 may be used. Based on the observed comparable or lower toxicity to fish it is considered unlikely that fish toxicity will be critical. Hence any additional toxicity testing with fish will not add scientific value to the ecotoxicity profile other than for obtaining a lower assessment factor. It is therefore concluded that for scientific reasons and in accordance to REACH legislation further testing on fish has to be avoided for reasons of animal welfare. This means that it is proposed to waive the long term fish unless a further refinement of the effect assessment is considered necessary based on the outcome of the chemical safety assessment.
Conclusion on classification
Ecotoxicity
Due to intrinsic properties of amine containing cationic surfactants river water ecotoxicity tests deliver more reproducible test results with limited uncertainty. As river water has a mitigating effect on ecotoxicity due to sorption of the amines to suspended matter a factor of 10 should be applied to the effect levels to correct for the lower ecotoxicity observed.
Table Available algae, daphnia and fish test results (Klimisch 1, 2 and 4)
Algae |
Fish |
Daphnia |
|
|
||
72 h EC50 (mg/L) |
72 h EC10 (mg/L) |
96 h LC50 (mg/L) |
21 d EC50 (mg/L) |
21 d EC10 (mg/L) |
EC50corr (mg/L) ** |
EC10corr (mg/L) **) |
0.085* |
0.015* |
0.58 |
0.5* |
0.28* |
0.0085 |
0.0015 |
* The fish test is performed in reconstitued lab water. After correction for the mitigation possibly caused by the use of river water, the lowest L(E)C50 is the algae EC50
**corrected for Classification with Factor 10
Biodegradability
The substance is readily biodegradable
Bioaccumulation potential
No measured BCF fish is available. Standard OECD 305 tests are technically very complicated with these strongly sorbing easily biodegradable substances. Based on a calculated log pow of 3.4 a low bioaccumulation potential is indicated for narcotic substances. For polar narcotics there is only limited information on the relationship between log Kow and BCF.
For hexadecyl amine rapid metabilisation in fish is anticipated based on in vitro metabolism test results with this substance (Kmet= 0.152 1/d; Bernard et al., 2006). Based on the structural similarity and ready biodegradability of N-[3-(dimethylamino)propyl]-C12-18(even numbered)-alkylamide similar metabolisation rates are expected for this substance. According to the REACH PBT guidance R.11, evidence of high biotransformation/metabolisation rate in fish may be used to support for arguing for a limited bioaccumulation potential but quantitative thresholds have not been established. The use of QSAR- and mechanistically-based bioaccumulation models is also considered valuable in the overall bioaccumulation assessment process. The BCFBAF model (v3.0) as included in EPIsuite (v4.0) is used to calculate a BCF. With a log Kow of 3.4 the BCF model predicts a log BCF of 1.46.
Classification according(Classification, Labeling & Packaging Directive 1272/2008/EC)
As all acute ecotoxicity values (corrected and uncorrected) as given in the first table are below 1 mg/L the substances should be classified as acute aquatic hazard category 1. The substance is ‘readily biodegradable’ and have a log Kow < 4. Based on long-term studies a classification for chronic aquatic toxicity is warranted according to 2nd ATP to CLP. This leads to the following environmental classification
Acute (short-term) aquatic hazard category 1
M factor acute 100
Chronic aquatic hazard category 1
M factor chronic 1
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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