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Diss Factsheets
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EC number: 202-180-8 | CAS number: 92-70-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Toxicity to reproduction: other studies
Additional information
When testing BONA in a one generation reproduction toxicity study in rats the outcome was as follows:
NOEL for systemic toxicity in P male: 12.5 mg/kg bw, based on forestomach lesions at 50 mg/kg bw.
NOEL for systemic toxicity P female: 50 mg/kg bw, based on forestomach lesions and adverse effects on bodyweight gain at 200 mg/kg/bw.
NOEL for reproductive toxicity P male 200 mg/kg bw (=highest dose tested).
NOEL for reproductive toxicity P female: 50 mg/kg bw, based on growth retardation of pups possibly related to suppressed lactation at 200 mg/kg/day.
NOEL for reproductive toxicity and teratogenicity F1 male/female: 50 mg/kg bw/day (=actual dose received by parental animals P), based on growth retardation (bodyweight of pups lower than concurrent controls) and malformations (in pups from a limited number of litters) at 200 mg/kg/day.
In summary, it can be stated that in this study male and female fertility (related to delivery performance) is not impaired. But there might be an effect via lactation causing a reduced body weight gain of the pups. Additionally malformations were observed in a limited number of litters appearing simultaneously with maternal toxicity at the highest dose tested.
In conclusion there are suspicious signs that the test item may cause harm via lactation and may cause malformations at doses associated with parenteral systemic toxicity. But for a final conclusion on classification without further testing available data alone were considered to be insufficient and not robust enough.
Justification for classification or non-classification
In summary, it can be stated that in this study male and female fertility (related to delivery performance) is not impaired. But there might be an effect via lactation causing a reduced body weight gain of the pups. Additionally malformations were observed in a limited number of litters appearing simultaneously with maternal toxicity at the highest dose tested.
In conclusion there are suspicious signs that the test item may cause harm via lactation and may cause malformations at doses associated with parenteral systemic toxicity. But for a final conclusion on classification without further testing available data alone were considered to be insufficient and not robust enough.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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