Registration Dossier

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Referenceopen allclose all

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
April-June 2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Type:
log Pow
Partition coefficient:
1.4
Temp.:
22 °C
pH:
6.9
Conclusions:
The log Pow for dimethyl adipate is 1.4.
Executive summary:

During this study the partition coefficient (n-octanol / water) of Reaction mass of Dimethyl adipate (CAS 627-93-0), Dimethyl glutarate (CAS 1119-40-0) and Dimethyl succinate (CAS 106-65-0) was determined using the HPLC- method as described in EEC Directive 92/69, A.8 “Partition Coefficient” (2008), the Council Regulation (EC) No. 440/2008, A.8 and in the OECD Guideline No. 117, “Partition Coefficient (n-Octanol / Water), High Performance Liquid Chromatography (HPLC) method” (2004).

Six common standards, which have known log POW values were used as reference standards. For the determination of the dead time a thiourea solution was used. From the regression curve (log k' vs. log POW) the n-octanol / water partition coefficient (log POW) of Reaction mass of

Dimethyl adipate (CAS 627-93-0), Dimethyl glutarate (CAS 1119-40-0) and Dimethyl succinate (CAS 106-65-0) at 22 °C was calculated to be

log Pow = 1.4 for Dimethyl adipate (CAS 627-93-0)

log Pow = 0.6 for Dimethyl succinate (CAS 106-65-0)

log Pow = 1.0 for Dimethyl glutarate (CAS 1119-40-0)

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Peer reviewed reference book.
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
GLP compliance:
no
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water
Type:
log Pow
Partition coefficient:
1.03
Temp.:
25 °C
Remarks on result:
other: The pH was neutral (6 - 8) and for a non ionizable substance such as this one, this parameter is not critical.

Description of key information

The partition coefficient between octanol and water is 1.4.

Key value for chemical safety assessment

Log Kow (Log Pow):
1.4
at the temperature of:
22 °C

Additional information