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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: data from OECD SIDS draft maleic acid

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Maleic Anhydride Toxicity and Health Summary
Author:
Eastman Kodak Company
Year:
1969
Bibliographic source:
Unpublished data from the Laboratory of Industrial Medicine, Eastman Kodak Company, Rochester, N.Y. Submitted to US EPA by Eastman Kodak Company as EPA Doc. No. 878214722; cited in OECD SIDS Draft Maleic Acid (2005)
Reference Type:
secondary source
Title:
Dangerous Properties of Industrial Materials
Author:
Sax, N. I. & Lewis, R.J.Sr.
Year:
1989
Bibliographic source:
Seventh edition. Vol III. Van Nostrand Reinhold, New York, U.S.A. #MAK609, p.2155; cited in OECD SIDS Draft Maleic Acid (2005)

Materials and methods

Principles of method if other than guideline:
Comparable to Draize test conditions; however, information on animal number occlusive conditions are missing
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
500 mg
Duration of treatment / exposure:
24 h
Observation period:
no data
Number of animals:
no data

Results and discussion

In vivo

Results
Irritation parameter:
other: irritation
Basis:
mean
Time point:
other: 24/48/72 hours
Score:
> 0
Remarks on result:
other: Application of 500 mg maleic acid for 24 hours produced mild skin irritation in the rabbit

Any other information on results incl. tables

Application of 500 mg maleic acid for 24 hours produced mild skin irritation in the rabbit

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU