Registration Dossier
Registration Dossier
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EC number: 203-742-5 | CAS number: 110-16-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment (questionable validity of the primary data source (IBT); reliability score from OECD SIDS Draft for Maleic Acid: 2)
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- BIOFAX Data Sheet 7-4/70
- Author:
- Industrial Bio-Test Laboratories Inc.
- Year:
- 1 970
- Bibliographic source:
- cited in Bibra International Ltd: Toxicity Profile - Maleic Acid, 1990
- Reference Type:
- secondary source
- Title:
- BIOFAX Data Sheet 7-4/70
- Author:
- Industrial Bio-Test Laboratories Inc.
- Year:
- 1 970
- Bibliographic source:
- cited in NIOSH, 1985
- Reference Type:
- secondary source
- Title:
- OECD SIDS
- Author:
- OECD SIDS
- Year:
- 2 005
- Bibliographic source:
- cited in OECD SIDS Draft Maleic Acid 01.09.2005
Materials and methods
- Principles of method if other than guideline:
- Unspecified test to determine the acute oral toxicity of maleic acid in rats.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Maleic acid
- EC Number:
- 203-742-5
- EC Name:
- Maleic acid
- Cas Number:
- 110-16-7
- Molecular formula:
- C4H4O4
- IUPAC Name:
- but-2-enedioic acid
- Details on test material:
- Maleic acid, no data on purity
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: no data
- Vehicle:
- not specified
- Doses:
- no data
- No. of animals per sex per dose:
- no data
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 708 mg/kg bw
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
