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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment (questionable validity of the primary data source (IBT); reliability score from OECD SIDS Draft for Maleic Acid: 2)

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
BIOFAX Data Sheet 7-4/70
Author:
Industrial Bio-Test Laboratories Inc.
Year:
1970
Bibliographic source:
cited in Bibra International Ltd: Toxicity Profile - Maleic Acid, 1990
Reference Type:
secondary source
Title:
BIOFAX Data Sheet 7-4/70
Author:
Industrial Bio-Test Laboratories Inc.
Year:
1970
Bibliographic source:
cited in NIOSH, 1985
Reference Type:
secondary source
Title:
OECD SIDS
Author:
OECD SIDS
Year:
2005
Bibliographic source:
cited in OECD SIDS Draft Maleic Acid 01.09.2005

Materials and methods

Principles of method if other than guideline:
Unspecified test to determine the acute oral toxicity of maleic acid in rats.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Maleic acid, no data on purity

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
other: no data
Vehicle:
not specified
Doses:
no data
No. of animals per sex per dose:
no data

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
708 mg/kg bw

Applicant's summary and conclusion