Registration Dossier
Registration Dossier
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EC number: 204-558-8 | CAS number: 122-62-3
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary literature. Original report not available.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Diesters Category of the Aliphatic Esters Chemicals (Test Plan and Robust Summaries for Substances in the HPV Test Plan)
- Author:
- US-EPA (American Chemistry Council's Aliphatic Esters Panel)
- Year:
- 2 010
- Bibliographic source:
- High Production Volume (HPV) Chemical Challenge Program (201-16837A and 201-16837B)
- Reference Type:
- secondary source
- Title:
- Toxicity Profile for Di(2-ethylhexyl) Sebacate
- Author:
- British Industrial Biological Research Association (BIBRA)
- Year:
- 1 996
- Bibliographic source:
- as cited in US-EPA (2010) Diesters Category of the Aliphatic Esters Chemicals
Materials and methods
- Principles of method if other than guideline:
- 1, 7, or 13-week inhalation study, no further details given.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Bis(2-ethylhexyl) sebacate
- EC Number:
- 204-558-8
- EC Name:
- Bis(2-ethylhexyl) sebacate
- Cas Number:
- 122-62-3
- Molecular formula:
- C26H50O4
- IUPAC Name:
- bis(2-ethylhexyl) sebacate
- Details on test material:
- - Analytical purity: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Remarks on MMAD:
- MMAD / GSD: no data
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 1, 7, or 13 weeks
- Frequency of treatment:
- 5 days/week; 4 h/day
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
25 and 250 mg/m³
Basis:
nominal conc.
- Remarks:
- Doses / Concentrations:
0.025 and 0.25 mg/L
Basis:
nominal conc.
- No. of animals per sex per dose:
- 12 rats/dose
- Control animals:
- yes
Results and discussion
Effect levels
- Dose descriptor:
- NOAEC
- Effect level:
- 250 mg/m³ air (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: no adverse systemic or lung effects at the highest concentration
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
There were no adverse systemic or lung effects seen in groups of 12 rats exposed to up to 250 mg/m³ for 4 h/day, 5 days/week for 13 weeks.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
