Registration Dossier
Registration Dossier
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EC number: 205-182-7 | CAS number: 135-19-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary citation. In the OECD SIDS on 2-Naphthol (2002) a similar reliability was assigned.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Industrial Bio-Test Laboratories, Inc., Data Sheets 26-4/1973.
- Author:
- Industrial Bio-Test Laboratories
- Year:
- 1 973
- Bibliographic source:
- As cited in: Berufsgenossenschaft der chemischen Industrie (1995): Toxikologische Bewertung. Beta-Naphthol. Nr. 135, Heidelberg and as cited in: The Registry of Toxic Effects of Chemical Substances (RTECS). 2-Naphthol.
Materials and methods
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-naphthol
- EC Number:
- 205-182-7
- EC Name:
- 2-naphthol
- Cas Number:
- 135-19-3
- Molecular formula:
- C10H8O
- IUPAC Name:
- 2-naphthol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 500 mg
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- Readings were made after 24 and 72 hours for erythema and edema.
- Number of animals:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Score:
- 1.29
- Reversibility:
- no data
- Remarks on result:
- other: The overall score (intact AND abraded skin) was given out of a scale of 8.0
- Irritation parameter:
- erythema score
- Score:
- 1.17
- Remarks on result:
- other: On abraded skin, erythema was still present after 72 hours
Any other information on results incl. tables
Erythema, but no edema was noted. On abraded skin, erythema was still present after 72 hours (score 1.17). The overall score (intact AND abraded skin) was given as 1.29 out of a scale of 8.0.
Applicant's summary and conclusion
- Conclusions:
- The result is described as "mild effects" in RTECS.
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