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Diss Factsheets
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EC number: 205-182-7 | CAS number: 135-19-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented study but no data on GLP compliance.
Data source
Reference
- Reference Type:
- publication
- Title:
- Effect of Microsomal Enzyme Inducing Agents on Hepatic Biotransformation in Cotton Rats (Sigmodon Hispidus): Comparison to that in Sprague-Dawley Rats.
- Author:
- Watkins JB
- Year:
- 1 991
- Bibliographic source:
- Comparative biochemistry and physiology. C. Comparative pharmacology and toxicology 1991, vol. 98, no2-3, pp. 433-439 [7 page(s) (article)]
Materials and methods
- Objective of study:
- metabolism
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-naphthol
- EC Number:
- 205-182-7
- EC Name:
- 2-naphthol
- Cas Number:
- 135-19-3
- Molecular formula:
- C10H8O
- IUPAC Name:
- 2-naphthol
- Details on test material:
- "highest quality available"
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Cotton (Sigmodon Hispidus) and Sprague-Dawley rats
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: Saline and corn oil
- Details on exposure:
- Assays were performed in duplicate or triplicate samples from each animal.
Separate groups of male animals were treated i.p. for four days with either 75 mg phenobarbital/kg in saline, 75 mg pregnenolone-16alpha-carbonitrile/kg suspended in 2% Tween 80 in saline, or 20 mg 2-methylcholanthrene/kg in corn oil.
Control animals received either corn oil or saline. - Duration and frequency of treatment / exposure:
- Duration of treatment: 4 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
All solutions were administered in a volume of 5 mL/kg.
- No. of animals per sex per dose / concentration:
- 6-8 animals male/ group
- Control animals:
- yes
- Details on dosing and sampling:
- All solutions were administered in a volume of 5 mL/kg. 24 hrs after the last dose, the rats were anesthetized with urethane and livers were excised, rinsed in ice-cold KCl, and a 25% homogenate in 0.25M sucrose was prepared (containing 10mM Tris-HCl, pH 7.4, and 3 mM 2-mercaptoethanol).
- Statistics:
- Means and standard errors were generated for each group, and the data were analyzed by a one-way or two-way analysis of variance as appropriate.Duncan`s new multiple range test was used to compare the means. Significance was set at P < 0.05.
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Sulfotransferase activity in male Sprague-Dawley rats for 2-naphthol was 0.641 +/- 0.021 nmol/min/mg protein (mean +/- SD for 15 rats). Sulfation in cotton rats was only 15-30% of that observed in SD rats and was not increased by inducer administration.
Applicant's summary and conclusion
- Conclusions:
- Sulfotransferase activity in male Sprague-Dawley rats for 2-naphthol was 0.641 +/- 0.021 nmol/min/mg protein (mean +/- SD for 15 rats). Sulfation in cotton rats was only 15-30% of that observed in SD rats and was not increased by inducer administration.
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