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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 200-819-5 | CAS number: 74-88-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7370 (Dissociation constants in water)
- GLP compliance:
- yes
- Dissociating properties:
- no
- Conclusions:
- Under the conditions of this study, no pKa activity was observed for the test material.
- Executive summary:
The dissociation constant of the test material was investigated in accordance with the standardised guideline OPPTS 830.7370, under GLP conditions.
Under the conditions of this study, no pKa activity was observed for the test material.
Reference
- The only difference in each overlay is the absorbance level at approximately 249 nm at each pH level. This difference is attributable to dilution effect in making pH adjustments (as expected, the pH adjusted spectrum provides the lowest absorption in each figure) .
- The principal requirements for determining a pKa by UV-vis are that the test material should absorb ultraviolet or visible light and that the absorption of the ion should differ from that of the molecule in wavelength and intensity (preferably both). The overlays indicate that the test material exhibits neither a wavelength difference across the pH range 2-10, nor does it exhibit an
absorbance difference due to ionisation. The test material does not demonstrate pKa activity by UV-vis absorption technique .
- The sharp inflection on the representative potentiometric titration (pHvs. mL, NaOH titrant) plot at approximately 10 mL is due to the expected HCl: NaOH (strong acid:strong base) equivalence point. No other inflections are evident. The reverse plot from approximately pH 2 to approximately pH 12 showed only the same expected matrix inflection and no other evident inflections. The duplicate test material solutions exhibited the same response. The absence of inflections other than matrix would indicate
that the test material does not exhibit pKa activity by potentiometric titration.
- The titrants, 0.1 N NaOH and 0.1 N HCI, were each checked prior to use. Inflections were noted within 10 ± 0.02 mL versus 10.00 mL theoretical.
- No pKa activity was observed for the test material. Differences in UV spectra were found to irreversible, and titrations revealed
only one expected matrix (strong acid/strong base) inflection and no observable inflections due to the test material.
Description of key information
Under the conditions of this study, no pKa activity was observed for the test material.
Key value for chemical safety assessment
Additional information
The dissociation constant of the test material was investigated in accordance with the standardised guideline OPPTS 830.7370, under GLP conditions. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).
Under the conditions of this study, no pKa activity was observed for the test material.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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