Registration Dossier
Registration Dossier
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EC number: 200-819-5 | CAS number: 74-88-4
pH
Administrative data
- Endpoint:
- pH
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11 May 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7000 (pH)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Iodomethane
- EC Number:
- 200-819-5
- EC Name:
- Iodomethane
- Cas Number:
- 74-88-4
- Molecular formula:
- CH3I
- IUPAC Name:
- iodomethane
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): Iodomethane
- Physical state: liquid
- Analytical purity: 99.7%
- Impurities (identity and concentrations): 0.2 % water and <0.1 % methanol
- Composition of test material, percentage of components: not stated
- Isomers composition: not stated
Constituent 1
Reagents
- Reagent:
- water
Results and discussion
pH value
- Key result
- pH value:
- 5.2
- Temp.:
- 25 °C
- Concentration:
- 1 other: % w/w
Any other information on results incl. tables
- The mean pH at 25.0 °C was 5.0. The individual pH values were 4.78 and 4.85 for replicate 1, and 5.45 and 5.45 for replicate 2. A second reading of each suspension was obtained since the pH value spread was wider than expected.
- pH 7.00 buffer checks at the beginning and end of experimentation were 6.96 and 7.03, respectively, indicating adequate instrument stability over the course of experimentation (within target ±0.05).
- After a discussion of the above results with the Sponsor, a second duplicate set of 1 % suspensions was prepared. The Sponsor representative was concerned with the observation of a suspension and not a solution at 1 % w/w level at 25 °C in water. After approximately 2.5 hours of equilibration at 25 °C, the individual pH values of each suspension were 5.05 for replicate 1 and 5.57 for replicate 2. The mean of 5.2 agrees well with 5.0 in the first experiment above.
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of this study the pH of the test material at 25 °C was 5.2.
- Executive summary:
The pH of the test material was determined in accordance with the standardised guideline OPPTS 830. 7000, under GLP conditions.
Under the conditions of this study the pH of the test material at 25 °C was 5.2.
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