Ester reaction products of 1,4-Benzenedicarboxylic acid with C11-14 iso-alcohols, C13-rich

Endpoint summary

Description of key information

The submission substance is not expected to produce acute or chronic toxicity in freshwater aquatic organisms (e.g., fish, invertebrates and algae) based on assessment of experimental data for the submission itself or read-across data for structurally related analogs [e.g., di-2-ethylhexyl terephthalate (DEHT) (CAS No. 6422-86-2)]. The absence of toxicity demonstrated by the submission substance is due in part to low water solubility, resulting in low exposure potential in the aqueous compartment as well as the ability of organisms to metabolize the test material at a rate which prevents a critical body burden from being reached. The data show that the submission substance is not toxic at its maximum water solubility limit [expected in the water accommodated fractions (WAF), water soluble fractions (WSF) or solubilized water dispersions] under the conditions of the tests. Since the submission substance does not cause acute or chronic toxic effects at the limits of water solubility, it was not possible to derive NOEC or PNEC values needed for quantitative risk assessment. However, it was possible to qualitatively conclude that based on low water solubility and the observed lack of acute and chronic aquatic toxicity, that the submission substance does not pose an unacceptable risk to the aquatic compartment. 

Owing to its inherently low water solubility and analytical difficulties in trying to determine the concentrations of the test material in water samples, the reported NOEL, EL50 or LL50 limit values used in support of hazard classification are inappropriate for risk assessment.