Registration Dossier
Registration Dossier
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EC number: 220-357-8 | CAS number: 2736-18-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Sept 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4,6-dichloro-1,3,5-triazin-2(1H)-one, sodium salt
- EC Number:
- 220-357-8
- EC Name:
- 4,6-dichloro-1,3,5-triazin-2(1H)-one, sodium salt
- Cas Number:
- 2736-18-7
- Molecular formula:
- C3HCl2N3O.Na
- IUPAC Name:
- 4,6-dichloro-1,3,5-triazin-2(1H)-one, sodium salt
- Test material form:
- liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 0.1 ml Solution of 4,6-dichloro-1,3,5-triazin-2(1H)-one, sodium salt, 8% in Water
- Duration of treatment / exposure:
- 1 hour
- Observation period (in vivo):
- 24/48/72 h
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- >= 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- >= 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- >= 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- >= 0
- Max. score:
- 0
- Reversibility:
- fully reversible
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- 4,6-dichloro-1,3,5-triazine-2(1H)-one, sodium salt is not irritating for the rabbit eye.
- Executive summary:
Under the test conditions a single instillation of 0.1 ml 4,6-dichloro-1,3,5-triazine-2(1H)-one, sodium salt 8% in Water per animal into the conjunctival sac of the right eye of three rabbits caused the following effects:
Conjunctival redness (grade 1) was noted in all animals 1 hour after instillation. The cornea and iris werde not affected by instillatoin of the test compound. There were no systemic intollerance reactions.
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