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EC number: 810-495-2 | CAS number: 93452-03-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Read-across, OECD Guideline 201, non-GLP, key study, validity 2:
72h-ErC50 growth rate (P. subcapitata) = 45.9 mg/L (nominal concentrations);
72h-NOECr growth rate (P. subcapitata) = 11.7 mg/L (nominal concentrations).
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 45.9 mg/L
- EC10 or NOEC for freshwater algae:
- 11.7 mg/L
Additional information
To assess the toxicity of the registered substance, METHYL CIS-3-OXO-2-PENTYL-1-CYCLOPENTANE ACETATE, to aquatic algae, one valid study is available.
This non-GLP study (Hotaka, 1998), assessed as a key study, was performed on a read-across substance, METHYL 3-OXO-2-PENTYL-1-CYCLOPENTANE ACETATE (quality High Trans isomer), according to OECD Guideline 201 (1984). This read-across substance is a mixture of two diastereomers, approximately 10% cis- and 90% trans-diastereomers of which the cis-diastereomer corresponds to the registered substance.
Pseudokirchnerella subcapitata was exposed to solutions of the test substance at nominal concentrations of 4.0, 6.8, 11.7, 20.0, 34.2, 58.5 and 100 mg/L for 72 hours, under constant illumination and shaking at a temperature of 23±2°C. The test substance solutions were prepared from a stock solution of test material in HCO-40 (1000 mg/l) and from a HCO-40 stock solution (1000 mg/l) to maintain final HCO-40 concentrations at 100 mg/l in all test conditions. Analytical monitoring was not performed as not required by the test guideline followed (1984). However,the test substance is expected to be stable in the test solution: OECD TG 111, half-life pH 7 > 1 year (this was confirmed with the long-term toxicity study on Daphnia magna where nominal concentrations were relatively well maintained during static renewal conditions: 74 to 101% of nominal values), has been shown to be moderately soluble (> 500 mg/L) and was not considered volatile in the physico-chemical studies.
Samples of the algal populations were removed at 24, 48 and 72h and cell concentrations were determined for each control, solvent control and treatment groups. Potassium dichromate was used as positive control.In terms of growth rate, exposure of Pseudokirchnerella subcapitata to the reference material, Potassium dichromate, gave an ErC50 (72 h) of 0.363 mg/L, a value in accordance with testing laboratory routine test results. In addition, exposure of Pseudokirchnerella subcapitata to the test substance gave an ErC50 (72 h) and a NOECr (72h) values of 45.9 mg/L and 11.7 mg/L, respectively.
This supporting substance is considered adequate for read-across purposes based on similar physico-chemical properties and the same ready biodegradability potential between the registered substance and the analogue material used.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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