Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 241-793-5 | CAS number: 17832-28-9
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriate low concentrations.
Key value for chemical safety assessment
Additional information
For 4 -(vinyloxy)butan-1 -ol a STP sluge respiration pre-guideline study is available which was however performed according to a method equivalent to OECD TG 209 (BASF, 1988). In this study a laboratory culture prepared from sludge taken from BASF sewage treatment plant was inoculated with nominal test substance concentrations of up to 1000 mg/L for a period of 30 minutes (reduced exposure period as volatilisation was expected to occur). Throughout the test a slight increase rather than decrease of respiration was recorded. based on these findings, the 30 -min NOEC in STP sluge is determined at ≥1000 mg/L. No detail is provided on whether the activated sludge used was or was not pre-exposed (i.e. adapted). However, based on the overall available data and consequent assessment of the biodegradation of 4 -(vinyloxy)butan-1 -ol, no significant toxicity to aquatic microorganisms is to be expected. Therefore the NOEC of 1000 mg/L is used for calculation of the PNECstp.
The afore stated is further supported by a test with the analogous substance isobutyl vinyl ether (CAS 109 -53 -5) which was conducted according to German Industrial Standard DIN 38412 part 27 (Robra-Test) (BASF, 1988). In this study bacteria cultures (P. putida) were exposed to test concentrations in the range of 1250 -10000 mg/L for a period of 17 hours. Based on the recorded oxygen consumption, an 17 -h EC10 of 3376 mg/L was determined. According to REACH guidance, data obtained with Pseudomas tests should be considered for assessment only when no other data is available. As other data is available, this data is considered as supporting information only.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
