Registration Dossier
Registration Dossier
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EC number: 942-438-3 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Oral: LD50= > 5000 mg/kg bw, male/female rat, equiv. to OECD 401, Biosearch Inc. 1979
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- The available information as a whole meets the tonnage driven information requirements of REACH.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The pre-GLP study was performed following a method similar to OECD 401 to assess the acute oral toxicity potential of the test substance to male/female Wistar rats. The test material was administered as a single oral dose to a group of 5 male and 5 female rats orally, at a dose level of 5000 mg/kg bodyweight. All animals were observed for a fourteen day period for any signs of toxicity or other effects of treatment. Animals were examined for gross pathology. One male died on Day 1 at this dose level. Lethargy, ataxia and ptosis were noted in all animals 3-4 hours post dose. All surviving animals were normal on Day 2. No remarkable findings were noted on necropsy. Under the conditions of this study the LD50 was determined to be >5000 mg/kg bw.
Justification for selection of acute toxicity – oral endpoint
Only one study available.
Justification for classification or non-classification
The substance does not meet classification criteria under Regulation (EC) No 1272/2008 for acute toxicity.
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