Registration Dossier
Registration Dossier
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EC number: 942-438-3 | CAS number: -
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
EL50 (invertebrates) = 2.11 mg/L ; WAF loading 48hour-freshwater, OECD TG 202, Dr.U.NOACK-Laboratorien 2015
Key value for chemical safety assessment
Additional information
The acute toxicity to Daphnia magna was carried out according to OECD 202 Daphnia sp., Acute Immobilisation Test and EU Method C.2 guidelines. The study was conducted in a closed system (sealed glass flasks) without headspace under semi-static conditions over a period of 48 hours with five Water Accommodated Fractions (WAF) of the test item with loading levels in the range of 0.772 to 8.10 mg/L prepared in a geometric series with a separation factor of 1.8. Twenty daphnids were exposed to each loading level and the control. The concentrations of the test item were analytically verified via GC-MS at the start (0 and 24 hours) and at the end of the exposure intervals (24 and 48 hours) in all concentration levels and the control. These analytical data were used as supporting information to monitor the stability of the three constituents of the test item in the test system during the study. The measured concentrations of the test item were in the range of 37 to 48 % of the 0 hour measured concentrations at 24 hours and 4 to 51 % of the 24 hour fresh test solution measured concentrations at 48 hours. The water quality parameters (i.e. pH-value and dissolved oxygen concentration), measured at the start (0 and 24 hours) and at the end of the exposure intervals (24 and 48 hours), were within the acceptable limits. The validity criteria of the test guideline were fulfilled. The 48h-EL50 was 2.11 mg/L (C.I: 1.76 – 2.51 mg/L) based on nominal loadings of the test item into the test system.
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