Registration Dossier
Registration Dossier
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EC number: 201-321-0 | CAS number: 81-07-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Possible mutagenic activity of saccharin
- Author:
- Renner, H. W.
- Year:
- 1 979
- Bibliographic source:
- Experientia 1979, 35, 1364.
- Reference Type:
- review article or handbook
- Title:
- DOSE doc.no. : S1
- Author:
- RSC Publishing
- Year:
- 2 011
- Bibliographic source:
- The Dictionary of Substances and their Effects:Renner, H. W. Experientia 1979, 35, 1364.
- Reference Type:
- review article or handbook
- Title:
- DPIM : BCE500
- Author:
- Richard J. Lewis, Sr.
- Year:
- 2 007
- Bibliographic source:
- SAX (Sax's Handbook of Dangerous Industrial Materials) : Experientia. 35 (1979), 1364.
- Reference Type:
- review article or handbook
- Title:
- RTECS Number: DE4200000
- Author:
- RTECS database
- Year:
- 2 012
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances); RTECS (Registry of Toxic Effects of Chemical Substances); EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 35,1364,1979
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Standard acute method
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- 1,2-benzisothiazol-3(2H)-one 1,1-dioxide
- EC Number:
- 201-321-0
- EC Name:
- 1,2-benzisothiazol-3(2H)-one 1,1-dioxide
- Cas Number:
- 81-07-2
- Molecular formula:
- C7H5NO3S
- IUPAC Name:
- 1,2-benzisothiazol-3(2H)-one 1,1-dioxide
- Details on test material:
- - Name of test material (as cited in study report): 1,2-benzisothiazol-3(2H)-one 1,1-dioxide
- Substance type: Organic
- Physical state: solid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 17 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Toxic effects not reported.
- Mortality:
- Lethal dose, 50 percent kill
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral median lethal dose (LD50) of 1,2-benzisothiazol-3(2H)-one 1,1-dioxide in mouse was found to be 17000 mg/kg of body weight. Acute toxicity of 1,2-benzisothiazol-3(2H)-one 1,1-dioxide to mouse by the oral route indicates that the substance does not exhibits acute toxicity by the oral route within the mentioned dose level.
- Executive summary:
The acute oral median lethal dose (LD50) of 1,2-benzisothiazol-3(2H)-one 1,1-dioxide in mouse was found to be 17000 mg/kg of body weight. Acute toxicity of 1,2-benzisothiazol-3(2H)-one 1,1-dioxide to mouse by the oral route indicates that the substance does not exhibits acute toxicity by the oral route within the mentioned dose level.
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