Registration Dossier
Registration Dossier
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EC number: 201-321-0 | CAS number: 81-07-2
Endpoint summary
Administrative data
Description of key information
Additional information
No. of studies of target substance 1,2-benzisothiazol-3(2H)-one 1,1-dioxide reviewed for bioaccumulation from reliable sources having Klimisch rating 2 and 4.
The summary of the results are presented below
Sr.No |
Endpoint |
Effect values |
Interpretation of results |
Species |
Sources |
1 |
BCF |
3.2 |
Non -bioaccumulative |
Fish |
Predicted data from PBT |
2 |
BCF |
3.162 |
Non -bioaccumulative |
Fish |
Predicted data from EPI Suite |
3 |
BCF |
1.58-2.1 |
Non -bioaccumulative |
Aquatic organisms |
Experimental data from Handbook of Chemical Property Estimation Methods |
4 |
BCF |
6.38 |
Non -bioaccumulative |
Fish |
Predicted data from QSAR |
By applying weight of evidence approach to the target substance 1,2-benzisothiazol-3(2H)-one 1,1-dioxide,the endpoint value of bioaccumulation was found to vary between BCF = 1.58 to 6.38 in aquatic organisms /fish.Thus it is concluded that the test substance 1,2-benzisothiazol-3(2H)-one 1,1-dioxide is not expected to bioaccumulate in the food chain because it does not exceed the BCF criteria.
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