Registration Dossier
Registration Dossier
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EC number: 208-008-8 | CAS number: 505-32-8
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets generally accepted scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- BASF-Test
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- - Name of test material (as cited in study report): Isophytol G
- Physical state: fluid
- Analytical purity: ca. 90 %
- Impurities (identity and concentrations): not reported
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Kißlegg, Allgäu
- Age at study initiation: no data
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: Traganth
- Details on exposure:
- Application as 1, 2, 4 and 20 % emulsion in Traganth.
- Doses:
- 100, 200, 400, 1600 µl/kg bw (corresponding to 84, 169, 338, 1350 mg/kg bw, based on a density of 0.844 g/cm³)
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 7 days (1350 and 169 mg/kg bw) and 14 days (338 and 84 mg/kg bw)
- Frequency of observations and weighing: weighing at begin of study, observations daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 169 mg/kg bw
- Remarks on result:
- other: 200 mm^3/kg bw, converted using a relative density of 0.844
- Mortality:
- 1350 mg/kg bw: 10/10 (1 h)
338 mg/kg bw: males 1/5 (7d), 2/5 (14 d); females 2/5 (7 d)
169 mg/kg bw: males 2/5 (48h) 3/5 (7 d); females 1/5 (48 h)
84 mg/kg bw: males 2/5 (14 d); females 0/5 - Clinical signs:
- 1350 mg/kg bw: directly after injection tachypnea, hollow flanks, apathy
338 mg/kg bw: scampering gait, staggering, tachypnea, hollow flanks, flattened ears, crouching position, ruffled fur, sticky eyes, irregular respiration, symptoms decreasing during observation period; without symptoms after 14 days
169 mg/kg bw: apathy, tachypnea, hollow flanks, ruffled fur, dyspnea, staggering, trembling, crouching position, sticky eyes, symptoms decreasing during observation period; without symptoms after 7 days
84 mg/kg bw: observations identical to 338 mg/kg bw dose group
Staggering, trembling, dyspnea - Gross pathology:
- Intrabadominal adhesions and incorporations of substance
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
